t(3;6)(p25;q26) QKI/RAF1

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

Location

6q26

Gene name

Location

3p25.2

Highly cited references

Pubmed IDYearTitleCitations
289121532017Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.79
288063932017CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles.21
305176582019Spinal Pleomorphic Xanthoastrocytoma With a QKI-RAF1 Fusion.2
339485632021Clinical utility of comprehensive genomic profiling in central nervous system tumors of children and young adults.1
350507122022Sustained Response to the Mitogen-Activated Extracellular Kinase Inhibitor Trametinib in a Spindle Cell Sarcoma Harboring a QKI-RAF1 Gene Fusion.0

Bibliography

Pubmed IDLast YearTitleAuthors
235839812013Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.Zhang J et al
288063932017CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles.Jain P et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(3;6)(p25;q26) QKI/RAF1

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/106146/t(3;6)(p25;q26)-qki-raf1