YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)

2003-02-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
YWHA1
FUSION GENES

Other Information

Locus ID:

NCBI: 7533
MIM: 113508
HGNC: 12853
Ensembl: ENSG00000128245

Variants:

dbSNP: 7533
ClinVar: 7533
TCGA: ENSG00000128245
COSMIC: YWHAH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128245ENST00000248975Q04917
ENSG00000128245ENST00000248975A0A024R1K7
ENSG00000128245ENST00000397492A2IDB1
ENSG00000128245ENST00000420430A2IDB2
ENSG00000128245ENST00000443669F8WEB6

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165451362006The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein.40
190343802009Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.36
12480176200214-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.16
176119842007Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation.16
191604472009Family-based association of YWHAH in psychotic bipolar disorder.15
191604472009Family-based association of YWHAH in psychotic bipolar disorder.15
245078842014Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.14
24751211201414-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage.13
111211722000Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia.12
121769952002MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.12

Citation

Dessen P

YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42860/ywhah