t(X;19)(q13;q13) CIC/FOXO4

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

CIC

Location

19q13.2

Gene name

FOXO4

Location

Xq13.1

Highly cited references

Pubmed IDYearTitleCitations
388820602024Molecular and therapeutic advancements in Capicua (CIC)-rearranged sarcoma.86
250102052014The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.62
393818432025Nuclear DUX4 immunohistochemistry is a highly sensitive and specific marker for the presence of CIC::DUX4 fusion in CIC-rearranged sarcomas: a study of 48 molecularly confirmed cases.37
256831832015High-grade undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: emerging entities of soft tissue tumors with unique histopathologic features--a case report and literature review.24
379008562023First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report.15
253213322014Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion.3
250071472014A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.0
282745122017Practical use and utility of fluorescence in situ hybridization in the pathological diagnosis of soft tissue and bone tumors.0
340573772022CRTC1-SS18 Fusion Sarcoma With Aberrant Anaplastic Lymphoma Kinase Expression.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
250071472014A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.Sugita S et al
250102052014The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.Brohl AS et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(X;19)(q13;q13) CIC/FOXO4

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/108657/t(x;19)(q13;q13)-cic-foxo4