A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32)

Petr Balicek, Jana Rabasova, Jiri Hak  

Division of Medical Genetics, University Hospital, 500 05 Hradec Kralove, Czech Republic

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
Down syndrome patient

Clinics case report

Age
17 yrs
Sex
M
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
32.9
Hb
7.7
Platelets
9
Blasts
90

Cyto path

Cytology
ALL - L1
Immunophenotype
CD10 (CALLA) positive; CD66 positive
Precise diagnosis
Early pre-B ALL

Survival data

Date diagnosis
04-2001
Treatment
Treated on protocol BFM 95 - medium risk group.
Complete remission
+ second cytogenetic examination: 47,XY,+21[70] - complete cytogenetic response.
Status
D
Survival
The patient died 1 month after diagnosis as a result of sepsis.

Karyotype

Sample
bone marrow
Culture time
24
Banding
R
Results
47,XY, der(14)t(8;14)(q11;q32),+21 'c' [17]/47,XY,+21 'c' [3]

Images

Atlas Image
der(14) t(8;14)(q11;q32) R- banding; the constitutional trisomy 21 is shown only on the bottom mitosis (left); chromosome 8 paint (right) - Petr Balicek, Jana Rabasova, Jiri Hak.

Comments section

Call for collab
- Isolated nucleic acids (both RNA and DNA) and cDNA from the second examination are available at the address below: Dr. Zdenek Fiedler - fiedler@lfhk.cuni.cz

Bibliography

Pubmed IDLast YearTitleAuthors
82425991993Two Down syndrome patients with an acquired translocation, t(8;14)(q11;q32), in early B-lineage acute lymphoblastic leukemia.Secker-Walker LM et al
86309901996Down syndrome, acute lymphoblastic leukemia, and t(8;14)(q11;q32)Lee AC et al
106737392000Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study.Kaleem Z et al
113057222001Relationship of chromosome 21 and acute leukemia in children with Down syndrome.Taub JW et al

Citation

Petr Balicek, Jana Rabasova, Jiri Hak

A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32)

Atlas Genet Cytogenet Oncol Haematol. 2001-06-01

Online version: http://atlasgeneticsoncology.org/case-report/208800/a-case-of-down-syndrome-with-acute-lymphoblastic-leukemia-and-t(8;14)(q11;q32)