The rare t(4;12)(q11;p13) in an elderly patient with de novo AML with multilineage dysplasia co-expressing stem cell markers

Sarah Moore, Sanjeev Chunilal, Jacqueline Beerworth  

(1)SA Cancer Cytogenetic Unit, Institute of Medical & veterinary Science, Adelaide, South Australia ; (2)Department of Haematology, The Queen Elizabeth Hospital, Adelaide, South Australia ; e-MAIL sarah.moore@imvs.sa.gov.au

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
-

Clinics case report

Age
84 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
30.2
Hb
11.8
Platelets
189
Bone marrow
20

Cyto path

Cytology
(FAB) M2 with maturation; myeloid/stem cell
Immunophenotype
CD13+, CD33+, CD7+, CD34+, CD117+, HLA-DR+
Rearranged ig tcr
-
Pathology
Numerous mononuclear megakaryocytes. Active erythropoiesis. Active granulopoiesis, hypogranular neutrophils, giant band forms, donut nuclei, pseudo Pelger-Huet anomalies. Blasts have moderate nuclear: cytoplasmic ratio.
Precise diagnosis
de novo AML with multilineage dysplasia

Survival data

Date diagnosis
03-2002
Treatment
Palliative treatment with oral etoposide
Complete remission
-
Treatment relat death
-
Status
D
Date last follow
07-2002
Survival
4

Karyotype

Sample
Bone marrow
Culture time
24
Banding
GTL
Results
46,XX,t(4;12)(q11;p13)[15]/46,XX[5]

Images

Atlas Image
t(4;12)(q11;p13) GTL banded

Comments section

Comments
This elderly woman did not receive induction chemotherapy. Her disease rapidly progressed from a smouldering leukaemia to a florid form. Findings are consistent with previous reports of t(4;12) with stem cell leukaemia in older patients, and with rarity of additional cytogenetic changes.

Bibliography

Pubmed IDLast YearTitleAuthors
91306131997Characterization of acute leukemia with t(4;12).Harada H et al
90127121997t(4;12)(q11;p13) in a CD7-negative acute myeloid leukaemia.Sainty D et al
104777091999Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).Cools J et al
105492631999A new translocation, t(2;4;12)(p21;q12;p13), in CD7-positive acute myeloid leukemia: a variant form of t(4;12).Hamaguchi H et al
117343252001Isochromosome (17)(q10) and translocation (4;12)(q12;p13) in a child with acute myeloid leukemia.Nathan PC et al

Citation

Sarah Moore, Sanjeev Chunilal, Jacqueline Beerworth

The rare t(4;12)(q11;p13) in an elderly patient with de novo AML with multilineage dysplasia co-expressing stem cell markers

Atlas Genet Cytogenet Oncol Haematol. 2002-08-01

Online version: http://atlasgeneticsoncology.org/case-report/208803/the-rare-t(4;12)(q11;p13)-in-an-elderly-patient-with-de-novo-aml-with-multilineage-dysplasia-co-expressing-stem-cell-markers