Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 2

Kavita S Reddy, Kathy Richkind Affiliation

Genzyme Genetics, Orange, CA. Kavita.reddy@gmail.com

Preleukaemia

Myelofibrosis

Malignant disease

A low-grade lobular and ductal carcinoma with a small percentage of intraductal breast disease treated with tamoxifen.

Age

61 yrs

Sex

Liver

Spleen

Lymph nodes

Cns involv

Wbc

3.05

8.1

Platelets

Precise diagnosis

Myelofibrosis -> acute leukemia

Treatment

Induction treatment: topotecan and cytarabine

Relapse

Status

Survival

55 +

Sample

Culture time

24/48 unstimulated cultures

Banding

G-banding

Results

46,X,t(X;20)(q13;q13.3),der(1;7)(q10;p10)[20]/46,XX[1]

Fig. 1. Partial karyotypes of the translocation t(X;20)(q13;q13.3) for cases 1ï4 (top to bottom). Arrows indicate the derivatives 20 and X.

Pubmed ID	Last Year	Title	Authors
7627939	1995	Biclonal acute monoblastic leukemia showing del(7q) and trisomies 9 and 22.	Wong KF et al
12606138	2003	Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders.	Gray BA et al
15676151	2005	Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders.	Reddy KS et al

Kavita S Reddy, Kathy Richkind

Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 2

Atlas Genet Cytogenet Oncol Haematol. 2005-01-01