t(4;12)(q11;p13) in an acute myeloid leukemia without maturation with myelodysplasia

Jean Philippe Rault  

CHR Bon Secours Géné

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
-

Clinics case report

Age
67 yrs
Sex
M
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
3,6
Hb
8,6
Platelets
151
Blasts
56
Bone marrow
Cellularity fewer than usual. Rare megakaryocytes, presence of micromegakaryocytes. Infiltration by blasts at a level of 58% with myeloid features. Dysgranulopoiesis > 10 % of non erythoblastic cells

Cyto path

Immunophenotype
CD34 (85%), HLA DR (91%) and myeloid cluster: CD11c (7%), CD13 (97%), CD13c (99%), CD33 (98%), CD117 (81%), MPO 5% and only one lymphoid cluster CD7 (87%). Conclusion: immature myeloid population. Phenotype FAB M0
Rearranged ig tcr
Not done
Pathology
Secondary Acute Respiratory desease due to a bilateral alveolar pneumopathy on June 2005, without suitable microbiological data, following an aplasia phase with fever at D+16 ( chemotherapy induction step)
Electron microscopy
No
Precise diagnosis
AML type Mo with myelodysplasia

Survival data

Date diagnosis
04-2005
Treatment
LAM SA 2002 Protocol. Idarubicine: 15mg per day from J1 to J5 / Aracytine: 180 mg per day from J1 to J7 / Belustine: 360 mg only at J1 then Aracytine and Idarubicine each three month during 15 days (6 cures).
Complete remission
Yes during induction phase
Treatment relat death
No
Relapse
No
Status
A
Date last follow
08-2005
Survival
5 +

Karyotype

Sample
Bone marrow
Culture time
24/48
Banding
R
Results
46, XY, t(4;12)(q11;p13.1) [27] / 46, XY [3]
Karyotype relapse
No relapse

Images

Atlas Image
t(4;12)(q11;p13.1) R-banding

Comments section

Comments
No AML/ETO t(8;21)(q22;q22) translocation, no split of MLL performed by FISH analysis

Bibliography

Pubmed IDLast YearTitleAuthors
117343252001Isochromosome (17)(q10) and translocation (4;12)(q12;p13) in a child with acute myeloid leukemia.Nathan PC et al

Citation

Jean Philippe Rault

t(4;12)(q11;p13) in an acute myeloid leukemia without maturation with myelodysplasia

Atlas Genet Cytogenet Oncol Haematol. 2005-09-01

Online version: http://atlasgeneticsoncology.org/case-report/208812/t(4;12)(q11;p13)-in-an-acute-myeloid-leukemia-without-maturation-with-myelodysplasia