t(8;13)(p12;q12) in an atypical chronic myeloid leukaemia case

Valeria AS De Melo, Alistair G Reid  

Leukaemia Cytogenetics Unit, G Block Room G124, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

Clinics case report

Age
43 yrs
Sex
M
Spleen
-
Lymph nodes
+

Blood data

Wbc
9.8
Hb
11.5
Platelets
28

Cyto path

Precise diagnosis
Atypical chronic myeloid leukaemia

Survival data

Date diagnosis
02-1992
Treatment
Chemo/Radiation/bone marrow transplantation
Complete remission
+
Treatment relat death
+
Relapse
-
Status
D
Date last follow
06-1994
Survival
28

Karyotype

Sample
Bone marrow
Culture time
CM FUDR 48 h
Banding
G-banding
Results
46,XY,t(8;13)(p12;q12)[8]/46,XY[2]

Images

Atlas Image
Partial karyotype showing the t(8;13)(p12;q12) - G-banding

Comments section

Comments
Eight of the metaphases examined showed a translocation between chromosomes 8 and 13. There was no evidence of a Philadelphia translocation. The t(8;13) is usually found in myeloproliferative syndromes with FGFR1 involvement and a poor prognosis

Bibliography

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Citation

Valeria AS De Melo, Alistair G Reid

t(8;13)(p12;q12) in an atypical chronic myeloid leukaemia case

Atlas Genet Cytogenet Oncol Haematol. 2006-12-01

Online version: http://atlasgeneticsoncology.org/case-report/208816/t(8;13)(p12;q12)-in-an-atypical-chronic-myeloid-leukaemia-case