Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne Affiliation

Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)

Previous history

Preleukaemia

Malignant disease

Inborn condition

Clinics case report

Age

59 yrs

Sex

Liver

Spleen

Lymph nodes

Cns involv

Blood data

Wbc

8.5

Platelets

600

Blasts

Cyto path

Cytology

Immunophenotype

Rearranged ig tcr

Pathology

MPD

Electron microscopy

Precise diagnosis

Atypical myeloproliferative disease, presenting polycythemia and thrombocythemia with myelofibrosis.

Survival data

Date diagnosis

09-1988

Treatment

Hydroxyurea

Complete remission

Treatment relat death

Relapse

Phenotype relapse

AML with unknown phenotype due to bone marrow aspiration failure.

Status

Date last follow

12-1997

Survival

111

Karyotype

Sample

bone marrow

Culture time

Banding

RHG

Results

47,XX,+9,-15,+dic(1;15)(p11;p11)[20]

Karyotype relapse

47,XX,t(1;6)(q21;q23),+9,-15,+dic(1;15)(p11;p11)[13]

Mol cytogenet technics

Other molec studies

Technics

Images

Partial karyotype (R-banding) at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 9.

Comments section

Comments

This is an additional MPD case presenting this recurrent abnormality, with a 10 years survival. However in this case the death is related to the GVH disease after allograft.

Bibliography

No bibliography items were found for this article.

Citation

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/case-report/208833/dic(1;15)(p11;p11)-as-a-non-random-abnormality-in-atypical-mpd