t(11;15)(q21;q26) CRTC3::MAML2

Genes involved

CRTC3 (15q26.1)

MAML2 (11q21)

Tumor type

Hidradenoma

mucoepidermoid carcinoma

Highly cited references

Pubmed IDYearTitleCitations
338787062021SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets.73
393929322025Comprehensive mutational profiling identifies new driver events in cutaneous leiomyosarcoma.64
393989062024Breast mucoepidermoid carcinoma with a rare CRTC3-MAML2 fusion.26
284382922017Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.26
230357862013Clinicopathological significance of MAML2 gene split in mucoepidermoid carcinoma.21
353922402022Gene Expression and Mutational Landscape in a PMEC Patient With Low to Intermediate-High Grade Transition.12
385768042024Left lower lobe sleeve resection for the clear cell variant of pulmonary mucoepidermoid carcinoma: A case report.12
334054002021Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.0
241211732013CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands.0
290791712017A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance.0
197497402009Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma.0
374221572023Genetic and Immunohistochemical Profiling of Mammary Hidradenoma and Comparison to Mucoepidermoid Carcinoma.0
274022172016Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions.0
389817502024Pulmonary mucoepidermoid carcinoma harboring the CRTC3-MAML2 fusion with a pure clear-cell composition: A case report.0
180503042008A new type of MAML2 fusion in mucoepidermoid carcinoma.0
343440722021[MAML2 gene rearrangement, fusion patterns and clinicopathological characteristics in primary pulmonary mucoepidermoid carcinoma].0
362080532023Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2- rearranged salivary gland tumours.0
216684762011Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma.0
241501952013CRTC3-MAML2 fusion transcript in a bronchial mucoepidermoid carcinoma.0
264573522015Warthin-like Mucoepidermoid Carcinoma: A Combined Study of Fluorescence In Situ Hybridization and Whole-slide Imaging.0
289307522018Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity.0
257827312015Thymic Mucoepidermoid Carcinoma: Report of a Case With CTRC1/3-MALM2 Molecular Studies.0
291314672018Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report.0
284122122017Mucoepidermoid carcinoma with extensive spindled morphology and melanocytic marker expression.0
397578622025Genomic and Transcriptomic Profiling of Digital Papillary Adenocarcinomas Reveals Alterations in Matrix Remodeling and Metabolic Genes.0

Bibliography

Pubmed IDPublication YearTitleAuthors
290791712017A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance.Kuma Y, et al
180503042008A new type of MAML2 fusion in mucoepidermoid carcinoma.Fehr A, et al
197497402009Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma.Nakayama T, et al
216684762011Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma.Okumura Y, et al
230357862013Clinicopathological significance of MAML2 gene split in mucoepidermoid carcinoma.Noda H, et al
338300802021The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma.Chen Z, et al