HMGA2::WIF1 (12q14)
Oncogenic mechanisms
upregulation of HMGA2 and downregulation of WIF1
Tumor type
The pleomorphic adenoma
Carcinoma ex pleomorphic adenoma
salivary gland tumors
Breast adenomyoepitheliomas
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32550265 | 2020 | Pleomorphic adenomas and mucoepidermoid carcinomas of the breast are underpinned by fusion genes. | 52 |
| 30675516 | 2019 | Assessment of HMGA2 and PLAG1 rearrangements in breast adenomyoepitheliomas. | 33 |
| 37849332 | 2024 | Expanding the histological spectrum of salivary gland neoplasms with HMGA2::WIF1 fusion emphasising their malignant potential: a report of eight cases. | 15 |
| 34324456 | 2022 | HMGA2-WIF1 Rearrangements Characterize a Distinctive Subset of Salivary Pleomorphic Adenomas With Prominent Trabecular (Canalicular Adenoma-like) Morphology. | 0 |
| 39089476 | 2024 | Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights. | 0 |
| 38266920 | 2024 | SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors. | 0 |
| 17171686 | 2007 | WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. | 0 |
| 38879353 | 2024 | The basaloid-spectrum of salivary gland tumors: A focused review with practical diagnostic considerations. | 0 |
| 36973206 | 2023 | [HMGA2-WIF1 rearranged salivary pleomorphic adenoma with trabecular/canalicular adenoma-like morphology: report of a case]. | 0 |
| 38708906 | 2024 | Peculiar nuclear atypia associated with MDM2 gene amplification in carcinoma ex-pleomorphic adenoma harbouring an alteration of HMGA2. | 0 |
| 21394649 | 2011 | Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study. | 0 |
| 21927843 | 2011 | PLAG1 expression in cutaneous mixed tumors: an immunohistochemical and molecular genetic study. | 0 |
| 38377962 | 2024 | Canalicular-Like Pleomorphic Adenoma of the Parotid Gland: A Recently Classified Tumor Highlighting the Use of Frozen Section Analysis and Surrogate IHC for Gene Rearrangement Defined Subtypes. | 0 |
| 18828159 | 2009 | High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 17171686 | 2007 | WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. | Queimado L, et al |
| 30675516 | 2019 | Assessment of HMGA2 and PLAG1 rearrangements in breast adenomyoepitheliomas. | Pareja F, et al |
| 32654217 | 2020 | Activation of PLAG1 and HMGA2 by gene fusions involving the transcriptional regulator gene NFIB. | Afshari MK, et al |
| 18828159 | 2009 | High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2. | Persson F, et al |
