t(7;7)(p15;q34) KLHL7::BRAF
Oncogenic mechanisms
Activation of MAPK pathway
Targeted therapy
Cobimetinib
trametinib
Tumor type
Thyroid carcinoma
giloblastoma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32466770 | 2020 | CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data. | 48 |
| 32590884 | 2020 | Congenital mesoblastic nephroma is characterised by kinase mutations including EGFR internal tandem duplications, the ETV6-NTRK3 fusion, and the rare KLHL7-BRAF fusion. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 26314551 | 2016 | The distribution of BRAF gene fusions in solid tumors and response to targeted therapy. | Ross JS, et al |
| 32466770 | 2020 | CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data. | Tian L, et al |
| 29617662 | 2018 | Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. | Gao Q, et al |
