PVT1::MYC (8q24)
Oncogenic mechanisms
Myc overexpression
Tumor type
Breast invasive carcinoma
acute myeloid leukemia
colon adenocarcinoma
esophagous adenocarcinoma
medulloblastoma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 27571409 | 2016 | RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. | 90 |
| 29669022 | 2018 | DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1. | 78 |
| 34040254 | 2021 | Enhancer release and retargeting activates disease-susceptibility genes. | 53 |
| 38625939 | 2024 | Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. | 52 |
| 38021073 | 2023 | Long non-coding RNA PVT1 (PVT1) affects the expression of CCND1 and promotes doxorubicin resistance in osteosarcoma cells. | 44 |
| 39376555 | 2024 | Construction of a novel model based on PVT1-MYC duet-related genes for predicting survival and characterization of the tumor microenvironment in pancreatic cancer. | 43 |
| 22832581 | 2012 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | 40 |
| 32992461 | 2020 | Long Noncoding RNA PVT1 Is Regulated by Bromodomain Protein BRD4 in Multiple Myeloma and Is Associated with Disease Progression. | 36 |
| 37503084 | 2023 | Phase separation of ecDNA aggregates establishes in-trans contact domains boosting selective MYC regulatory interactions. | 34 |
| 27115168 | 2016 | Integrating understanding of epidemiology and genomics in B-cell non-Hodgkin lymphoma as a pathway to novel management strategies. | 30 |
| 27308428 | 2015 | The PVT1-MYC duet in cancer. | 10 |
| 31932969 | 2020 | The expression of MYC is strongly dependent on the circular PVT1 expression in pure Gleason pattern 4 of prostatic cancer. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 22101766 | 2011 | Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. | Robinson DR, et al |
| 22952423 | 2012 | Gene fusions associated with recurrent amplicons represent a class of passenger aberrations in breast cancer. | Kalyana-Sundaram S, et al |
| 33600954 | 2021 | PVT1: A long non-coding RNA recurrently involved in neoplasia-associated fusion transcripts. | Tolomeo D, et al |
