Translocation t(8;14)(q24;q32) as a clue for the diagnosis of B cell prolymphocytic leukemia

Genes involved

IGH (14q32.33)

MYC (8q24.21)

Tumor type

B cell prolymphocytic leukemia

Highly cited references

Pubmed IDYearTitleCitations
291323232017Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma.87
377462542023Clinicopathological analysis of diffuse large B-cell lymphoma using molecular biomarkers: a retrospective analysis from 7 Hungarian centers.74
375559802023Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.68
345217522021DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.65
312217832020Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma.54
254821992014Nucleolar tethering mediates pairing between the IgH and Myc loci.53
3034964720183'Igh enhancers hs3b/hs4 are dispensable for Myc deregulation in mouse plasmacytomas with T(12;15) translocations.50
355630172022Enhancer RNA AL928768.3 from the IGH Locus Regulates MYC Expression and Controls the Proliferation and Chemoresistance of Burkitt Lymphoma Cells with IGH/MYC Translocation.49
299037642018Inferior survival in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements is not associated with MYC/IG gene rearrangements.44
176395842007In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development.41
159880162005Sites that direct nuclear compartmentalization are near the 5' end of the mouse immunoglobulin heavy-chain locus.40
163548392005Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.39
237757152013A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma.37
385383172024Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization.35
275665742016Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human.32
204538902010Genetic reporter system for oncogenic Igh-Myc translocations in mice.31
227264972012Sporadic Burkitt lymphomas of children and adolescents in Chinese: a clinicopathological study of 43 cases.31
272179702016Validation of break-apart and fusion MYC probes using a digital fluorescence in situ hybridization capture and imaging system.30
229156502012IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas.30
291120162018B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement: Report of 3 Cases in Adult Patients.29
384685552024Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge.26
286342242017IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors.20
333813292020Double-Hit Primary Plasma Cell Leukemia with IGH/MYC and IGH/CCND1 Translocations.20
275123412016Concomitant Classic Hodgkin Lymphoma of Lymph Node and cMYC-Positive Burkitt Leukemia/Lymphoma of the Bone Marrow Presented Concurrently at the Time of Presentation: A Rare Combination of Discordant Lymphomas.20
318728612020Comparison Between Integrated Genomic DNA/RNA Profiling and Fluorescence In Situ Hybridization in the Detection of MYC, BCL-2, and BCL-6 Gene Rearrangements in Large B-Cell Lymphomas.19
350243322022Anaplastic multiple myeloma with MYC rearrangement.18
389092662024Transformation of t(14;18)-negative follicular lymphoma to plasmablastic lymphoma: a case report with analysis of genetic evolution.17
194544962009Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma.17
230495642012Burkitt lymphoma presenting as unilateral deafness in an immunocompetent patient.16
344727202022Genetic features of precursor B-cell phenotype Burkitt leukemia with IGH-MYC rearrangement.15
253811332015A rare case of IGH/MYC and IGH/BCL2 double hit primary plasma cell leukemia.14
348687692021Adult Nodal Burkitt Lymphoma Forming Nodular Architectures.14
311603602019Elucidating a false-negative MYC break-apart fluorescence in situ hybridization probe study by next-generation sequencing in a patient with high-grade B-cell lymphoma with IGH/MYC and IGH/BCL2 rearrangements.13
333395352020Double-hit lymphoma of the male breast: a case report.13
223898852012A case of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma in a Korean child.13
361718382022Burkitt Lymphoma of the Appendix Presenting With Acute Appendicitis and Acute Kidney Injury: A Case Report and Review of Literature.12
300129202018Transformation of double-hit follicular lymphoma to plasmablastic lymphoma: a partial role of MYC gene rearrangement.11
381754452023B-lymphoblastic leukemia/lymphoma with MYC and BCL2 gene rearrangements shows evidence for clonal evolution and mitotic recombination.10
396627842024Burkitt lymphoma.0
387227412024Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma.0
374856492023Unexpected MYC::DMD translocation after transformation of follicular lymphoma with IGH::BCL2 and IGH::MYC.0
316950022019[Aggressive B-cell lymphoma with IGH/MYC, IGH/BCL2, and IGH/CCND1 translocations].0
357660672022Looking for the truth: an IGH-MYC+ lymphoid neoplasm with immature B-cell phenotype (CD34 positivity) successfully treated with Burkitt lymphoma protocol.0
233076012013Double-hit myeloma with IGH/MYC and IGH/CCND1 translocations.0
158524722005Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas.0
19063441991Transcriptional deregulation of myc in IgH/myc 6;7 translocation carrying rat immunocytomas.0
168151052006Myc translocations in B cell and plasma cell neoplasms.0
83143301994Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc.0
317057722020Molecular characteristics of terminal deoxynucleotidyl transferase negative precursor B-cell phenotype Burkitt leukemia with IGH-MYC rearrangement.0
161409302005Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice.0
371862592023Transformations of marginal zone lymphomas and lymphoplasmacytic lymphomas: Report from the 2021 SH/EAHP Workshop.0
311721912019Histiocytic Sarcoma Following B-Lymphoblastic Leukemia/Lymphoma.0
237959462013MYC status determination in aggressive B-cell lymphoma: the impact of FISH probe selection.0
381754042023"Quadruple-hit" primary testicular diffuse large B-cell lymphoma with MYD88 L265P mutation, IGH::MYC, and IRF4- and BCL6-rearrangements.0
92909471997Immunoglobulin/Myc recombinations in murine Peyer's patch follicles.0
318317192019Molecular Cytogenetic Characterization of a Three-way t(8;14;22)(q24;q32;q11.2) with Involvement of MYC/IGH/IGL in a Case of a Diffuse Large B-cell Lymphoma (DLBCL).0
385698572024[Multiple myeloma with IgH::MYC and multiple extramedullary lesions].0
241184982014MYC translocation partner gene determines survival of patients with large B-cell lymphoma with MYC- or double-hit MYC/BCL2 translocations.0
370945462023Comprehensive FISH testing using FFPE tissue microarray of primary lymph node tissue identifies secondary cytogenetic abnormalities in Mantle Cell Lymphoma.0
168886152006Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2.0
26452211989Reversion of tumorigenicity and decreased agarose clonability after EBV conversion of an IgH/myc translocation-carrying BL line.0
203030182010Detection of cryptic and variant IGH-MYC rearrangements in high-grade non-Hodgkin's lymphoma by fluorescence in situ hybridization: implications for cytogenetic testing.0
263736762015MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study.0
124810062002Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features.0
380327392024How Many Tests Does It Take to Diagnose a Triple-Hit B-Lymphoblastic Lymphoma? (Hint, It's A Lot).0
151915632004Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas.0
309830442019The accuracy of diagnosing Burkitt lymphoma in serous effusion specimen: A cytological-histological correlation with ancillary studies.0
186480002008Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice.0
296299472019Identification of "Double Hit" Lymphomas Using Updated WHO Criteria: Insights From Routine MYC Immunohistochemistry in 272 Consecutive Cases of Aggressive B-Cell Lymphomas.0
379061382023[Genetic analysis of two cases with MYC "negative" Burkitt lymphoma].0
246689462014Conventional and molecular cytogenetic characterization of Burkitt lymphoma with bone marrow involvement in Brazilian children and adolescents.0
163274382005Adult B-cell lymphomas with burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior.0
243361562014Rearrangements of MYC gene facilitate risk stratification in diffuse large B-cell lymphoma patients treated with rituximab-CHOP.0
368816392023Integrated Genomic DNA/RNA Profiling vs Fluorescence in Situ Hybridization in the Detection of MYC and BCL2 (and BCL6) Rearrangements in Large B-Cell Lymphomas: Updates Amid the New WHO Classification of Lymphoid Neoplasms.0
207997672010Primary bilateral Burkitt lymphoma of the lactating breast: a case report and review of the literature.0
255365682014MYC gene rearrangements detected by interphase fluorescence in situ hybridization in diffuse large B-cell lymphomas.0
157510442005Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation.0
283882792017Investigation of AID, Dicer, and Drosha Expressions in Patients with Chronic Lymphocytic Leukemia.0
285151002017Detection of Chromosomal Translocation in Hematologic Malignancies by a Novel DNA-Based Looped Ligation Assay (LOLA).0
193369592009CD20-negative CD138-positive leukemic large cell lymphoma with plasmablastic differentiation with an IgH/MYC translocation in an HIV-positive patient.0
385220752024High-grade B-cell lymphoma with a quadruple-hit genetic profile including concurrent MYC, BCL2, BCL6, and CCND1 gene rearrangements.0
98657131998High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies.0
213192572011Identification of IGHCδ-BACH2 fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B-cell lymphoma/leukemia.0
174057442007AIDS-related plasmablastic lymphoma of the oral cavity associated with an IGH/MYC translocation--treatment with autologous stem-cell transplantation in a patient with severe haemophilia-A.0
121397452002Philadelphia chromosome-positive mature B-cell (Burkitt cell) leukaemia.0
212150972010[Molecular genetic features of sporadic Burkitt's lymphoma in children].0
259481772015[Cytogenetic characteristics of 163 children with acute lymphoblastic leukemia].0
309634742019Double-hit pancreatic B-lymphoblastic lymphoma with a variant translocation t(2;18)(p11;q21).0
196537142009Chromosomal 3 and 8 status within hepatic metastasis of uveal melanoma.0
298821662018Co-fuse: a new class discovery analysis tool to identify and prioritize recurrent fusion genes from RNA-sequencing data.0
158438272005Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.0
117224122001Blastic mantle cell lymphoma associated with Burkitt-type translocation and hypodiploidy.0
166161072006Burkitt t(8;14)(q24;q32) and cryptic deletion in a CLL patient: report of a case and review of literature.0
265490902015Primary Burkitt's lymphoma of the breast without Epstein-Barr virus infection: A case report and literature review.0
229581762012Plasmablastic lymphoma of the elderly: a clinicopathological comparison with age-related Epstein-Barr virus-associated B cell lymphoproliferative disorder.0
210808892010A case of plasmablastic lymphoma harbouring an IgH/MYC translocation in a HIV negative individual.0
220182722011A novel five-way translocation, t(3;9;13;8;14)(q27;p13;q32;q24;q32), with concurrent MYC and BCL6 rearrangements in a primary bone marrow B-cell lymphoma.0
211206442010Modified cyclophosphamide, vincristine, doxorubicin, and methotrexate (CODOX-M)/ifosfamide, etoposide, and cytarabine (IVAC) therapy with or without rituximab in Japanese adult patients with Burkitt lymphoma (BL) and B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and BL.0
152913672004Burkitt's lymphoma of the stomach: a case report with molecular cytogenetic analysis.0
400202102025Challenging Conventional Diagnostic Methods by Comprehensive Molecular Diagnostics: A Nationwide Prospective Comparison in Children With ALL.0

Bibliography

Pubmed IDPublication YearTitleAuthors