t(3;6)(q12;q22) TFG::ROS1
Oncogenic mechanisms
Constitutive activation of ROS1 tyrosine kinase activity
Targeted therapy
Crizotinib
Entrectinib
Tumor type
Inflammatory myofibroblastic tumor
atypical meningioma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38622850 | 2024 | Reclassification of a spindle cell sarcoma after identification of a TFG-ROS1 fusion: A case demonstrating the clinical benefit of next-generation sequencing in sarcoma. | 43 |
| 25723109 | 2015 | Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement. | 41 |
| 25612511 | 2015 | Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors. | 38 |
| 37950626 | 2024 | Individualized targeted treatment in a case of a rare TFG::ROS1 fusion positive inflammatory myofibroblastic tumor (IMT). | 38 |
| 38787978 | 2024 | Two cases of inflammatory myofibroblastic tumor treated with targeted drugs: A case report. | 13 |
| 36730016 | 2023 | A Novel CASC15-ALK and TFG-ROS1 Fusion Observed in Uterine Inflammatory Myofibroblastic Tumor. | 0 |
| 36226472 | 2022 | Curable response to crizotinib in a patient with liver metastatic inflammatory myofibroblastic tumour carrying a TFG-ROS1 fusion. | 0 |
| 34157012 | 2021 | Rapid Response to Lorlatinib in a Patient With TFG-ROS1 Fusion Positive Inflammatory Myofibroblastic Tumor of the Chest Wall Metastatic to the Brain and Refractory to First and Second Generation ROS1 Inhibitors. | 0 |
| 34059352 | 2021 | Durable response to serial tyrosine kinase inhibitors (TKIs) in an adolescent with metastatic TFG-ROS1 fusion positive Inflammatory Myofibroblastic Tumor (IMT). | 0 |
| 32064735 | 2020 | Gene rearrangements in consecutive series of pediatric inflammatory myofibroblastic tumors. | 0 |
| 35543076 | 2022 | Histologic characterization of paediatric mesenchymal neoplasms treated with kinase-targeted therapy. | 0 |
| 26647767 | 2016 | ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumours. | 0 |
| 28449809 | 2017 | Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma. | 0 |
| 25293980 | 2015 | Adult-onset inflammatory myofibroblastic tumour of the stomach with a TFG-ROS1 fusion. | 0 |
| 31805529 | 2019 | Partial Response to Ceritinib in a Patient With Abdominal Inflammatory Myofibroblastic Tumor Carrying a TFG-ROS1 Fusion. | 0 |
| 31690781 | 2020 | Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases. | 0 |
| 37263929 | 2023 | [TFG-ROS1 fusion positive inflammatory myofibroblastoma of uterus: report of a case]. | 0 |
| 34814185 | 2021 | Molecular Characterization of Inflammatory Tumors Facilitates Initiation of Effective Therapy. | 0 |
| 34145176 | 2021 | Therapeutic options in inoperable ROS1-rearranged inflammatory myofibroblastic tumor of the tongue in a child: a case report and literature review. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 24875859 | 2014 | Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions. | Lovly CM, et al |
| 28449809 | 2017 | Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma. | Rossing M, et al |
| 25723109 | 2015 | Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement. | Antonescu CR, et al |
