inv(1)(q21q23)TPM3::NTRK1
Oncogenic mechanisms
Constitutive activation of TRK pathway
Targeted therapy
Larotrectinib
entrectinib
Tumor type
Thyroid carcinoma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 25527197 | 2015 | TRKing down an old oncogene in a new era of targeted therapy. | 90 |
| 32737449 | 2020 | Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization. | 67 |
| 35172474 | 2021 | Development of an RNA sequencing panel to detect gene fusions in thyroid cancer. | 66 |
| 31567189 | 2020 | Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature. | 59 |
| 38967220 | 2024 | Neurotrophic tyrosine receptor kinase gene fusions in adult and pediatric patients with solid tumors: a clinicogenomic biobank and record linkage study of expression frequency and patient characteristics from Finland. | 52 |
| 37534190 | 2023 | Overcoming MET-mediated resistance in oncogene-driven NSCLC. | 51 |
| 24962792 | 2014 | The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition. | 50 |
| 34790577 | 2021 | Anti-Tumor Activity of AZD4547 Against NTRK1 Fusion Positive Cancer Cells Through Inhibition of NTRKs. | 48 |
| 29125233 | 2017 | In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs. | 48 |
| 38923428 | 2024 | Induction of resistance to neurotrophic tropomyosin-receptor kinase inhibitors by HMGCS2 via a mevalonate pathway. | 45 |
| 38984028 | 2024 | Poor outcome in congenital mesoblastic nephroma with TPM3::NTRK1 fusion: a case report from multi-disciplinary treatment to molecular tumor board. | 42 |
| 26892443 | 2016 | The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing. | 42 |
| 26716414 | 2016 | NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer. | 38 |
| 35237889 | 2022 | Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers. | 35 |
| 31442744 | 2019 | Cancer Panel Assay for Precision Oncology Clinic: Results from a 1-Year Study. | 34 |
| 27259011 | 2016 | Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors. | 33 |
| 33923728 | 2021 | NTRK Fusion Genes in Thyroid Carcinomas: Clinicopathological Characteristics and Their Impacts on Prognosis. | 32 |
| 37075810 | 2023 | LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients. | 32 |
| 29568395 | 2018 | Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors. | 30 |
| 28877062 | 2018 | Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas: Expanding the Genetic Spectrum of Tumors With Overlapping Features With Infantile Fibrosarcoma. | 29 |
| 33768710 | 2021 | Identification of NTRK gene fusions in lung adenocarcinomas in the Chinese population. | 28 |
| 40011900 | 2025 | NTRK rearranged spindle cell neoplasm of the uterine cervix: a rare case report and literature review. | 28 |
| 29553955 | 2018 | NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma. | 27 |
| 33707574 | 2021 | NTRK fusion in Japanese colorectal adenocarcinomas. | 26 |
| 34659525 | 2021 | TRK inhibitors block NFKB and induce NRF2 in TRK fusion-positive colon cancer. | 26 |
| 39802876 | 2024 | TPM3::NTRK1-rearranged uterine sarcoma: case report and literature review. | 24 |
| 40021757 | 2025 | An accurate DNA and RNA based targeted sequencing assay for clinical detection of gene fusions in solid tumors. | 24 |
| 34723848 | 2022 | NTRK-Fusion Sarcoma of the Uterine Cervix: Report of 2 Cases With Comparative Clinicopathologic Features. | 23 |
| 38357202 | 2024 | Case report: Adult NTRK-rearranged spindle cell neoplasms with TPM3-NTRK1 fusion in the pelvic. | 22 |
| 29610391 | 2018 | Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma. | 22 |
| 38835742 | 2024 | Difficulties of Preoperative Diagnosis of Cribriform Morular Thyroid Carcinoma. | 22 |
| 26472021 | 2015 | NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line. | 19 |
| 35251641 | 2022 | A rare case of recurrent ovarian cancer with TPM3-NTRK1 gene rearrangement: A case report. | 13 |
| 33219493 | 2022 | Infantile fibrosarcoma with TPM3-NTRK1 fusion in a boy with Bloom syndrome. | 12 |
| 26563355 | 2016 | Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer. | 12 |
| 32939344 | 2020 | TMP3-NTRK1 rearranged uterine sarcoma: A case report. | 11 |
| 36652666 | 2023 | Marked Response to Larotrectinib in Pelvic Spindle Cell Sarcoma With Concurrent TPM3-NTRK1 Fusion and CDK4/MDM2 Amplification: A Case Report. | 6 |
| 32169993 | 2020 | TPM3-NTRK1 fusion in a pleomorphic xanthoastrocytoma presenting with haemorrhage in a child. | 5 |
| 25384085 | 2014 | Anchored multiplex PCR for targeted next-generation sequencing. | 0 |
| 30171197 | 2019 | Molecular characterization of cancers with NTRK gene fusions. | 0 |
| 7590742 | 1995 | A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. | 0 |
| 33631044 | 2021 | NTRK fusion-positive colorectal cancer in Japanese population. | 0 |
| 37142453 | 2023 | Elaboration of NTRK-rearranged colorectal cancer: Integration of immunoreactivity pattern, cytogenetic identity, and rearrangement variant. | 0 |
| 36586421 | 2023 | CANTRK: A Canadian Ring Study to Optimize Detection of NTRK Gene Fusions by Next-Generation RNA Sequencing. | 0 |
| 28751539 | 2017 | Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers. | 0 |
| 38525823 | 2024 | Primary NTRK -rearranged Spindle Cell Neoplasm of the Gastrointestinal Tract: A Clinicopathological and Molecular Analysis of 8 Cases. | 0 |
| 35149769 | 2022 | Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements. | 0 |
| 10074915 | 1999 | NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accident. | 0 |
| 26001971 | 2015 | Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma. | 0 |
| 39316650 | 2024 | Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue. | 0 |
| 35543076 | 2022 | Histologic characterization of paediatric mesenchymal neoplasms treated with kinase-targeted therapy. | 0 |
| 35007853 | 2022 | Pan-tumor screening for NTRK gene fusions using pan-TRK immunohistochemistry and RNA NGS fusion panel testing. | 0 |
| 35404193 | 2023 | Infant-Type Hemispheric Glioma in a Chinese Girl: A Newly Defined Entity. | 0 |
| 32610377 | 2020 | [Clinicopathological characteristics of NTRK-rearranged mesenchymal tumors in childhood]. | 0 |
| 33128780 | 2021 | Chromosomal imbalances detected in NTRK-rearranged sarcomas by the use of comparative genomic hybridisation. | 0 |
| 30668525 | 2019 | Targetable gene fusions identified in radioactive iodine refractory advanced thyroid carcinoma. | 0 |
| 34402529 | 2021 | NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions. | 0 |
| 32669612 | 2021 | Mesenchymal tumors of the gastrointestinal tract with NTRK rearrangements: a clinicopathological, immunophenotypic, and molecular study of eight cases, emphasizing their distinction from gastrointestinal stromal tumor (GIST). | 0 |
| 38866255 | 2024 | Feasibility of two-step approach for screening NTRK fusion in two major subtypes of non-small cell lung cancer within a large cohort. | 0 |
| 35977594 | 2022 | Pan-tropomyosin receptor kinase immunohistochemistry is a feasible routine screening strategy for NTRK fusions in mismatch repair-deficient colorectal carcinomas. | 0 |
| 34091760 | 2021 | Correlating SS18-SSX immunohistochemistry (IHC) with SS18 fluorescent in situ hybridization (FISH) in synovial sarcomas: a study of 36 cases. | 0 |
| 26200269 | 2015 | Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung. | 0 |
| 39720993 | 2024 | A phase II trial of larotrectinib in tumors with NTRK fusions or extremes of NTRK mRNA overexpression identified by comprehensive genomic profiling. | 0 |
| 33986460 | 2021 | Re-evaluating tumors of purported specialized prostatic stromal origin reveals molecular heterogeneity, including non-recurring gene fusions characteristic of uterine and soft tissue sarcoma subtypes. | 0 |
| 29463555 | 2018 | Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion-Positive Tumor Cells in a Brain Metastasis Model. | 0 |
| 30877273 | 2019 | Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms. | 0 |
| 32591465 | 2020 | U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors. | 0 |
| 37106286 | 2023 | [Clinicopathological features of gastric carcinomas with NTRK-rearrangement/amplification: report of four cases]. | 0 |
| 35220354 | 2022 | Primary NTRK-rearranged Spindle Cell Neoplasm of the Lung: A Clinicopathologic and Molecular Analysis of 3 Cases. | 0 |
| 39863528 | 2025 | [NTRK gene fusion and molecular pathological characteristics of mismatch repair deficient colorectal cancer]. | 0 |
| 31971278 | 2020 | NTRK fusion cervical sarcoma: a report of three cases, emphasising morphological and immunohistochemical distinction from other uterine sarcomas, including adenosarcoma. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 7590742 | 1995 | A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. | Butti MG, et al |
| 1384673 | 1992 | Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas. | Sozzi G, et al |
| 25204415 | 2014 | The landscape of kinase fusions in cancer. | Stransky N, et al |
| 25500544 | 2015 | The landscape and therapeutic relevance of cancer-associated transcript fusions. | Yoshihara K, et al |
