inv(1)(q23q31)TPR::NTRK1
Oncogenic mechanisms
Constitutive activation of TRK pathway
Targeted therapy
Larotrectinib
entrectinib
Tumor type
LPF-like neural tumors
Uterine sarcomas
Thyroid carcinomas
Colon adenocarcinoma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32737449 | 2020 | Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization. | 67 |
| 31567189 | 2020 | Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature. | 59 |
| 32755586 | 2020 | Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer. | 53 |
| 32957984 | 2020 | Clinicopathological findings of pediatric NTRK fusion mesenchymal tumors. | 38 |
| 34237031 | 2021 | NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake. | 33 |
| 27259011 | 2016 | Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors. | 33 |
| 32457407 | 2020 | Clinicopathologic and molecular characterization of NTRK-rearranged thyroid carcinoma (NRTC). | 33 |
| 33923728 | 2021 | NTRK Fusion Genes in Thyroid Carcinomas: Clinicopathological Characteristics and Their Impacts on Prognosis. | 32 |
| 33755158 | 2021 | Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes. | 30 |
| 29553955 | 2018 | NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma. | 27 |
| 26367451 | 2016 | Molecular Characterization of Sporadic Pediatric Thyroid Carcinoma with the DNA/RNA ThyroSeq v2 Next-Generation Sequencing Assay. | 27 |
| 33707574 | 2021 | NTRK fusion in Japanese colorectal adenocarcinomas. | 26 |
| 38642578 | 2024 | Predictors of radioiodine (RAI)-avidity restoration for NTRK fusion-positive RAI-resistant metastatic thyroid cancers. | 26 |
| 9172002 | 1997 | Chromosome 1 rearrangements involving the genes TPR and NTRK1 produce structurally different thyroid-specific TRK oncogenes. | 0 |
| 33118176 | 2021 | p53 immunohistochemical analysis of fusion-positive uterine sarcomas. | 0 |
| 26001971 | 2015 | Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma. | 0 |
| 35034013 | 2022 | A Unique Case Report of Infant-Type Hemispheric Glioma (Gliosarcoma Subtype) with TPR-NTRK1 Fusion Treated with Larotrectinib. | 0 |
| 37061245 | 2023 | Intestinal infantile fibrosarcoma with translocation of NTRK. A case report and review of the literature. | 0 |
| 32489127 | 2021 | A Case of Inv(1)(q23q31) TPR-NTRK1 Fusion-Positive Spindle Cell Neoplasm in an Infant-Uncovered by Next-Generation Sequencing: Diagnostic Challenge, Review, and Therapeutic Implications. | 0 |
| 10074915 | 1999 | NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accident. | 0 |
| 39729556 | 2024 | A Case of NTRK Fusion Corpus Sarcoma With Pseudobiphasic Growth Pattern and Literature Review. | 0 |
| 34402529 | 2021 | NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions. | 0 |
| 32669612 | 2021 | Mesenchymal tumors of the gastrointestinal tract with NTRK rearrangements: a clinicopathological, immunophenotypic, and molecular study of eight cases, emphasizing their distinction from gastrointestinal stromal tumor (GIST). | 0 |
| 32827026 | 2020 | The Clinicopathological Results of Thyroid Cancer With BRAFV600E Mutation in the Young Population of Fukushima. | 0 |
| 34464935 | 2021 | Novel fusion sarcomas including targetable NTRK and ALK. | 0 |
| 30475255 | 2019 | Distinct Genomic Patterns in Pigmented Epithelioid Melanocytoma: A Molecular and Histologic Analysis of 16 Cases. | 0 |
| 31792356 | 2020 | NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas-a study of 4569 cases. | 0 |
| 28351223 | 2017 | Identification of Three Novel Fusion Oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET, in Thyroid Cancers of Young Patients in Fukushima. | 0 |
| 31971278 | 2020 | NTRK fusion cervical sarcoma: a report of three cases, emphasising morphological and immunohistochemical distinction from other uterine sarcomas, including adenosarcoma. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 27259011 | 2016 | Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors. | Agaram NP, et al |
| 29553955 | 2018 | NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma. | Chiang S, et al |
| 26784937 | 2016 | NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. | Prasad ML, et al |
| 26001971 | 2015 | Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma. | Créancier L, et al |
| 9172002 | 1997 | Chromosome 1 rearrangements involving the genes TPR and NTRK1 produce structurally different thyroid-specific TRK oncogenes. | Greco A, et al |
