FGFR1::TACC1 (8p11)
Oncogenic mechanisms
Constitutive activation of FGFR signaling
Tumor type
Extraventricular neurocytoma
Gastrointestinal stromal tumor
Glioblastoma
Uterine sarcoma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 27245147 | 2016 | FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review). | 137 |
| 32085805 | 2020 | FGFR- gene family alterations in low-grade neuroepithelial tumors. | 78 |
| 38607246 | 2024 | FGFR1 fusions as a novel molecular driver in rhabdomyosarcoma. | 61 |
| 38195220 | 2025 | Clinicopathological analysis of BRAF and non-BRAF MAPK pathway-altered gliomas in paediatric and adult patients: a single-institution study of 40 patients. | 59 |
| 27974047 | 2016 | FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors. | 49 |
| 32859279 | 2020 | Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor. | 44 |
| 17137506 | 2006 | FGFR1 and WT1 are markers of human prostate cancer progression. | 44 |
| 33346834 | 2021 | High frequency of disease progression in pediatric spinal cord low-grade glioma (LGG): management strategies and results from the German LGG study group. | 42 |
| 39378520 | 2024 | Recurrent symptomatic intracranial hemorrhage in high-grade astrocytoma with piloid features: illustrative case. | 34 |
| 36446043 | 2022 | Rare FGFR Oncogenic Alterations in Sequenced Pediatric Solid and Brain Tumors Suggest FGFR Is a Relevant Molecular Target in Childhood Cancer. | 33 |
| 25669975 | 2015 | Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers. | 32 |
| 35949590 | 2022 | PTCH1 mutant small cell glioblastoma in a patient with Gorlin syndrome: A case report. | 29 |
| 37695397 | 2023 | Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications. | 22 |
| 34734147 | 2021 | FGFR1-TACC1 fusion associated with malignant transformation in a primary spinal cord glioma: a case report. | 11 |
| 36302190 | 2022 | Uterine Sarcoma With FGFR1-TACC1 Gene Fusion: A Case Report and Review of the Literature. | 0 |
| 29978331 | 2018 | FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma. | 0 |
| 35064610 | 2022 | The novel finding of an FGFR1::TACC1 fusion in an undifferentiated spindle cell sarcoma of soft tissue with aggressive clinical course. | 0 |
| 35343428 | 2022 | Histologically heterogeneous pediatric glioneuronal tumor with FGFR1::TACC1 fusion. | 0 |
| 30379640 | 2019 | The role of fibroblast growth factors and their receptors in gliomas: the mutations involved. | 0 |
| 33481389 | 2021 | Neurofibrosarcoma Revisited: An Institutional Case Series of Uterine Sarcomas Harboring Kinase-related Fusions With Report of a Novel FGFR1-TACC1 Fusion. | 0 |
| 33212490 | 2021 | Spinal Cord Pilocytic Astrocytoma With FGFR1-TACC1 Fusion and Anaplastic Transformation. | 0 |
| 34580728 | 2021 | Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death. | 0 |
| 35347013 | 2022 | Oncogenic Fusions in Gliomas: An Institutional Experience. | 0 |
| 34749374 | 2022 | Leptomeningeal Dissemination of Low-Grade Neuroepithelial Tumor with FGFR1_TACC1 Fusion with Clinical and Radiographic Response to Pazopanib and Topotecan. | 0 |
| 38976815 | 2024 | Midline Low-Grade Gliomas of Early Childhood: Focus on Targeted Therapies. | 0 |
| 28863456 | 2017 | Multiplex Detection of Pediatric Low-Grade Glioma Signature Fusion Transcripts and Duplications Using the NanoString nCounter System. | 0 |
| 12684693 | 2003 | Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 29978331 | 2018 | FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma. | Sievers P, et al |
| 32085805 | 2020 | FGFR- gene family alterations in low-grade neuroepithelial tumors. | Bale TA, et al |
| 27974047 | 2016 | FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors. | Shi E, et al |
| 22837387 | 2012 | Transforming fusions of FGFR and TACC genes in human glioblastoma. | Singh D, et al |
| 33481389 | 2021 | Neurofibrosarcoma Revisited: An Institutional Case Series of Uterine Sarcomas Harboring Kinase-related Fusions With Report of a Novel FGFR1-TACC1 Fusion. | Devereaux KA, et al |
