t(11;11)(q21;q22) YAP1::MAML2
Tumor type
nasopharyngeal carcinoma
Poroma/porocarcinoma
Skin Cutaneous Melanoma
pleomorphic xanthoastrocytoma/ pediatric high grade glioma
Retiform and composite hemangioendotheliomas
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35158743 | 2022 | Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors. | 171 |
| 30485824 | 2018 | Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines. | 105 |
| 33674910 | 2021 | Molecular pathology of thymomas: implications for diagnosis and therapy. | 72 |
| 38067300 | 2023 | The Role of Gene Fusions in Thymic Epithelial Tumors. | 67 |
| 31097696 | 2019 | Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening. | 59 |
| 37658696 | 2024 | Untying the Gordian knot of composite hemangioendothelioma: Discovery of novel fusions. | 49 |
| 24214394 | 2014 | Discovery of recurrent structural variants in nasopharyngeal carcinoma. | 44 |
| 36344258 | 2023 | Malignant undifferentiated epithelioid neoplasms with MAML2 rearrangements: A clinicopathologic study of seven cases demonstrating a heterogenous entity. | 39 |
| 34791601 | 2022 | Whole Exome Sequencing Identifies Somatic Variants in an Oral Composite Hemangioendothelioma Characterized by YAP1-MAML2 Fusion. | 38 |
| 31906059 | 2019 | Molecular Profiling of Atypical Tenosynovial Giant Cell Tumors Reveals Novel Non-CSF1 Fusions. | 38 |
| 36008139 | 2022 | Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice. | 35 |
| 39624057 | 2024 | The YAP1-MAML2 fusion drives tumorigenesis and sustains tumor growth. | 34 |
| 31145701 | 2019 | Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma. | 33 |
| 39417927 | 2024 | Comprehensive Next Generation Sequencing Reveals that Purported Primary Squamous Cell Carcinomas of the Parotid Gland are Genetically Heterogeneous. | 28 |
| 34354947 | 2021 | YAP1-MAML2 Fusion as a Diagnostic Biomarker for Metaplastic Thymoma. | 27 |
| 32504288 | 2021 | YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor. | 23 |
| 32991341 | 2020 | Recurrent YAP1 and MAML2 Gene Rearrangements in Retiform and Composite Hemangioendothelioma. | 22 |
| 37628996 | 2023 | Atypical Intraparenchymal Meningioma with YAP1-MAML2 Fusion in a Young Adult Male: A Case Report and Mini Literature Review. | 21 |
| 37489594 | 2023 | Significance of YAP1-MAML2 rearrangement and GTF2I mutation in the diagnosis and differential diagnosis of metaplastic thymoma. | 15 |
| 35986430 | 2022 | YAP1-MAML2 fusion in a pediatric NF2-wildtype intraparenchymal brainstem schwannoma. | 13 |
| 38864046 | 2024 | Hide-and-Seek With Spindle-Cell-Component-Poor Metaplastic Thymoma. | 12 |
| 35734511 | 2022 | Poromas with YAP1-MAML2 fusions in a poromatosis case. | 11 |
| 39091554 | 2024 | Metaplastic thymoma in the middle mediastinum: a rare case report and surgical treatment analysis of a 32-year-old female patient. | 11 |
| 36207139 | 2022 | Modeling YAP fusions: a paradigm for investigating rare cancers? | 9 |
| 37229516 | 2023 | Giant Multilocular-Cystic Metaplastic Thymoma: A Case Report. | 9 |
| 39450936 | 2025 | A woman with mycosis fungoides, vitiligo, and a new hand nodule. | 6 |
| 35598201 | 2022 | A novel YAP1-MAML2 fusion in an adult supra-tentorial ependymoma, YAP1-fused. | 0 |
| 37565303 | 2023 | Loss of YAP1 C-terminus expression as an ancillary marker for metaplastic thymoma: a potential pitfall in detecting YAP1::MAML2 gene rearrangement. | 0 |
| 36853792 | 2023 | Expanding the Clinicopathologic Spectrum of YAP1::MAML2-Rearranged Thymic Neoplasm. | 0 |
| 36723803 | 2023 | YAP1::MAML2 fusions in poromatosis: A report of two patients. | 0 |
| 35546636 | 2022 | Recurrent YAP1::MAML2 fusions in "nodular necrotizing" variants of myxoinflammatory fibroblastic sarcoma: a comprehensive study of 7 cases. | 0 |
| 37199682 | 2023 | Recurrent PAK2 rearrangements in poroma with folliculo-sebaceous differentiation. | 0 |
| 31641231 | 2020 | Metaplastic thymoma: a distinctive thymic neoplasm characterized by YAP1-MAML2 gene fusions. | 0 |
| 36720791 | 2023 | Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1-deficient skin carcinoma. | 0 |
| 36788097 | 2023 | Response to "Expanding the Clinicopathologic Spectrum of YAP1-MAML2-Rearranged Thymic Neoplasm". | 0 |
| 37505808 | 2023 | Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey. | 0 |
| 38058040 | 2023 | [Clinicopathological and molecular features of metaplastic thymoma]. | 0 |
| 38785043 | 2024 | Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases. | 0 |
| 39034412 | 2024 | Squamous Cell Carcinoma Arising in YAP1::MAML2 Fusion-Associated Metaplastic Thymoma: A Case Report. | 0 |
| 33222286 | 2021 | Utility of YAP1 and NUT immunohistochemistry in the diagnosis of porocarcinoma. | 0 |
| 39096416 | 2024 | Immunohistochemistry for YAP1 N-terminus and C-terminus highlights metaplastic thymoma and high-grade thymic epithelial tumors by different staining patterns. | 0 |
| 33704800 | 2021 | Poroid adnexal skin tumors with YAP1 fusions exhibit similar histopathologic features: A series of six YAP1-rearranged adnexal skin tumors. | 0 |
| 38088454 | 2024 | Spindle cell porocarcinoma with a novel YAP1::MAML3 fusion. | 0 |
| 33994171 | 2021 | Spindle cell/sclerosing rhabdomyosarcoma with a novel YAP1-MAML2 fusion in a 1-year-old: not all strongly TRK-expressing spindle cell sarcomas in infants are infantile fibrosarcomas! | 0 |
| 35665951 | 2022 | Molecular analysis of NUT-positive poromas and porocarcinomas identifies novel break points of YAP1::NUTM1 fusions. | 0 |
| 39242440 | 2024 | Malignant meningioma of the falx cerebri in a child: case report and literature review. | 0 |
| 39985924 | 2025 | Anaplastic meningioma in a 6-year-old with somatic YAP1::MAML2 fusion and multiple endocrine neoplasia type 4 (MEN4) syndrome. | 0 |
| 39023557 | 2024 | Conundrum of 3N: nasopharyngeal nonkeratinizing non-viral carcinoma-reappraisal of fusions and report of two consecutive cases with unusual molecular findings. | 0 |
| 36794976 | 2023 | Porocarcinoma with YAP1-NUTM1 fusion presenting as a NUT immunohistochemistry-positive lymph node metastasis. | 0 |
| 37093756 | 2024 | A Rare Case of Metaplastic Thymoma Presenting With Myasthenia Gravis. | 0 |
| 39822017 | 2025 | A Clinicopathologic and Molecular Reappraisal of Myxoinflammatory Fibroblastic Sarcoma-A Controversial and Pathologically Challenging Low-Grade Sarcoma. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 24214394 | 2014 | Discovery of recurrent structural variants in nasopharyngeal carcinoma. | Valouev A, et al |
| 31145701 | 2019 | Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma. | Sekine S, et al |
| 29617662 | 2018 | Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. | Gao Q, et al |
| 31734728 | 2020 | YAP1-fusions in pediatric NF2-wildtype meningioma. | Sievers P, et al |
| 32991341 | 2020 | Recurrent YAP1 and MAML2 Gene Rearrangements in Retiform and Composite Hemangioendothelioma. | Antonescu CR, et al |
