GOPC::ROS1 (6q22)
Oncogenic mechanisms
Constitutive activation of ROS1 tyrosine kinase activity
Targeted therapy
Crizotinib
Entrectinib
Tumor type
Lung adenocarcinoma
Glioma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 22163003 | 2011 | Chromosome 3 anomalies investigated by genome wide SNP analysis of benign, low malignant potential and low grade ovarian serous tumours. | 78 |
| 34875133 | 2022 | Detection of gene mutations and gene-gene fusions in circulating cell-free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis. | 61 |
| 38195220 | 2025 | Clinicopathological analysis of BRAF and non-BRAF MAPK pathway-altered gliomas in paediatric and adult patients: a single-institution study of 40 patients. | 59 |
| 37537783 | 2023 | Rare FGFR fusion genes in cervical cancer and transcriptome-based subgrouping of patients with a poor prognosis. | 58 |
| 31995621 | 2020 | Clinical management and genomic profiling of pediatric low-grade gliomas in Saudi Arabia. | 52 |
| 30171048 | 2018 | Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma. | 51 |
| 36053834 | 2022 | ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer. | 50 |
| 38254850 | 2024 | Translation into Clinical Practice of the G1-G7 Molecular Subgroup Classification of Glioblastoma: Comprehensive Demographic and Molecular Pathway Profiling. | 46 |
| 23052255 | 2012 | Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. | 38 |
| 34599262 | 2021 | Recurrence-associated gene signature in patients with stage I non-small-cell lung cancer. | 35 |
| 28912153 | 2017 | Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures. | 33 |
| 37075810 | 2023 | LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients. | 32 |
| 38845690 | 2024 | Prolonged response to entrectinib in an adult patient with recurrent glioblastoma harboring a GOPC::ROS1 fusion. | 25 |
| 32652753 | 2020 | Successful Treatment of Patients with Refractory High-Grade Serous Ovarian Cancer with GOPC-ROS1 Fusion Using Crizotinib: A Case Report. | 24 |
| 34076666 | 2021 | Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi. | 16 |
| 34536122 | 2021 | GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types. | 11 |
| 33733342 | 2021 | GOPC-ROS1 mosaicism in agminated Spitz naevi: report of two cases. | 0 |
| 24999209 | 2014 | Lack of GOPC-ROS1 (FIG-ROS1) rearrangement in adult human gliomas. | 0 |
| 31626289 | 2019 | GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. | 0 |
| 31929384 | 2020 | Oncogenic GOPC-ROS1 Fusion Identified in a Congenital Glioblastoma Case. | 0 |
| 37532182 | 2023 | ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients. | 0 |
| 29935846 | 2018 | GOPC-ROS1 Rearrangement as an Acquired Resistance Mechanism to Osimertinib and Responding to Crizotinib Combined Treatments in Lung Adenocarcinoma. | 0 |
| 36707425 | 2023 | Genomic and epigenomic re-categorization of congenital glioblastoma and desmoplastic infantile ganglioglioma. | 0 |
| 35172482 | 2017 | Acral Lentiginous Melanoma Harboring a ROS1 Gene Fusion With Clinical Response to Entrectinib. | 0 |
| 28844173 | 2017 | Clinical Application of Whole Genome Array Improves the Diagnosis of Pediatric Brain Tumors. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 23052255 | 2012 | Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. | Suehara Y, et al |
| 23877438 | 2013 | CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. | Matsuura S, et al |
| 28387643 | 2017 | Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor. | Kiehna EN, et al |
