del(1)(q22q23) LMNA::NTRK1
Oncogenic mechanisms
Constitutive activation of TRK pathway
Targeted therapy
Larotrectinib
entrectinib
Tumor type
Infantile fibrosarcoma
lipofibromatosis
undifferentiated pleomorphic sarcoma
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30633925 | 2019 | New fusion sarcomas: histopathology and clinical significance of selected entities. | 86 |
| 31567189 | 2020 | Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature. | 59 |
| 31653970 | 2019 | Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients. | 53 |
| 38014853 | 2024 | Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing. | 50 |
| 32860002 | 2021 | Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions. | 50 |
| 38254850 | 2024 | Translation into Clinical Practice of the G1-G7 Molecular Subgroup Classification of Glioblastoma: Comprehensive Demographic and Molecular Pathway Profiling. | 46 |
| 31015311 | 2019 | Molecular Profiling of Tumor Tissue and Plasma Cell-Free DNA from Patients with Non-Langerhans Cell Histiocytosis. | 46 |
| 36258694 | 2022 | Survival benefit of combinatorial osimertinib rechallenge and entrectinib in an EGFR-mutant NSCLC patient with acquired LMNA-NTRK1 fusion following osimertinib resistance. | 40 |
| 32957984 | 2020 | Clinicopathological findings of pediatric NTRK fusion mesenchymal tumors. | 38 |
| 26716414 | 2016 | NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer. | 38 |
| 38925616 | 2024 | Prevalence of neurotrophic tropomyosin receptor kinase (NTRK) fusion gene positivity in patients with solid tumors in Japan. | 35 |
| 35237889 | 2022 | Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers. | 35 |
| 36801905 | 2023 | Generating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy. | 33 |
| 35366592 | 2022 | Standardized evidence-based approach for assessment of oncogenic and clinical significance of NTRK fusions. | 32 |
| 30709876 | 2019 | Refractory and metastatic infantile fibrosarcoma harboring LMNA-NTRK1 fusion shows complete and durable response to crizotinib. | 32 |
| 26216294 | 2015 | An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. | 32 |
| 34625502 | 2021 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. | 31 |
| 29553955 | 2018 | NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma. | 27 |
| 36357104 | 2022 | Intestinal LMNA::NTRK1-fused spindle cell neoplasm with S100 and CD34 coexpression: a new case. | 26 |
| 32348852 | 2020 | Enrichment of kinase fusions in ESR1 wild-type, metastatic breast cancer revealed by a systematic analysis of 4854 patients. | 25 |
| 39988443 | 2025 | [A Case Report of Lung Adenocarcinoma with EGFR G719A Mutation and LMNA-NTRK1 Fusion]. | 24 |
| 32782782 | 2020 | Successful treatment of lipofibromatosis-like neural tumor of the lumbar spine with an NTRK-fusion inhibitor. | 24 |
| 38104989 | 2024 | LMNA::NTRK1 Fusion-positive Leiomyosarcoma: Discrepancy between DNA-based Comprehensive Genomic Profiling and RNA Sequencing. | 18 |
| 28719467 | 2017 | Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions. | 17 |
| 30134855 | 2018 | A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report. | 17 |
| 26563355 | 2016 | Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer. | 12 |
| 26747892 | 2016 | Tracking Down Response and Resistance to TRK Inhibitors. | 10 |
| 34667475 | 2021 | Unusual Presentation of Lipofibromatosis-Like Neural Tumor in an Adult: A Case Report. | 10 |
| 29892662 | 2018 | Lipofibromatosis-like neural tumor: Case report of a unique infantile presentation. | 9 |
| 33354405 | 2021 | Dermoscopic Features of Spitz Tumor With LMNA-NTRK1 Fusion. | 2 |
| 26563357 | 2016 | N of 2 Responders with LMNA-NTRK1. | 0 |
| 36162033 | 2022 | Adultes Xanthogranulom mit LMNA-NTRK1-Genfusion - ein möglicher Proliferationsfaktor. | 0 |
| 36028468 | 2022 | Adult xanthogranuloma with LMNA-NTRK1 gene fusion - a possible driver of proliferation. | 0 |
| 28683589 | 2018 | Infantile NTRK-associated Mesenchymal Tumors. | 0 |
| 32519338 | 2021 | LMNA-NTRK1 rearranged mesenchymal tumor (lipofibromatosis-like neural tumor) mimicking pigmented dermatofibrosarcoma protuberans. | 0 |
| 33631044 | 2021 | NTRK fusion-positive colorectal cancer in Japanese population. | 0 |
| 38613194 | 2024 | Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model. | 0 |
| 39412335 | 2025 | LMNA::NTRK1 and PRDX1::NTRK1 Atypical Spitz Tumor: A Report of Two Additional Cases With Histological, Immunohistochemical, and Molecular Insights. | 0 |
| 36586421 | 2023 | CANTRK: A Canadian Ring Study to Optimize Detection of NTRK Gene Fusions by Next-Generation RNA Sequencing. | 0 |
| 34628036 | 2021 | Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors. | 0 |
| 38525823 | 2024 | Primary NTRK -rearranged Spindle Cell Neoplasm of the Gastrointestinal Tract: A Clinicopathological and Molecular Analysis of 8 Cases. | 0 |
| 35149769 | 2022 | Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements. | 0 |
| 37142453 | 2023 | Elaboration of NTRK-rearranged colorectal cancer: Integration of immunoreactivity pattern, cytogenetic identity, and rearrangement variant. | 0 |
| 27617936 | 2016 | Generalized eruptive histiocytosis associated with a novel fusion in LMNA-NTRK1. | 0 |
| 28851664 | 2018 | Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. | 0 |
| 38653403 | 2024 | Prevalence and detection methodology for preliminary exploration of NTRK fusion in gastric cancer from a single-center retrospective cohort. | 0 |
| 33069129 | 2020 | Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors. | 0 |
| 26546295 | 2016 | Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer. | 0 |
| 33168793 | 2020 | Comprehensive analysis of ALK, ROS1 and RET rearrangements in locally advanced rectal cancer. | 0 |
| 32610377 | 2020 | [Clinicopathological characteristics of NTRK-rearranged mesenchymal tumors in childhood]. | 0 |
| 35977594 | 2022 | Pan-tropomyosin receptor kinase immunohistochemistry is a feasible routine screening strategy for NTRK fusions in mismatch repair-deficient colorectal carcinomas. | 0 |
| 34402529 | 2021 | NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions. | 0 |
| 32669612 | 2021 | Mesenchymal tumors of the gastrointestinal tract with NTRK rearrangements: a clinicopathological, immunophenotypic, and molecular study of eight cases, emphasizing their distinction from gastrointestinal stromal tumor (GIST). | 0 |
| 26563356 | 2016 | Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib. | 0 |
| 34518039 | 2022 | Detection of NTRK fusions in glioblastoma: fluorescent in situ hybridisation is more useful than pan-TRK immunohistochemistry as a screening tool prior to RNA sequencing. | 0 |
| 35220354 | 2022 | Primary NTRK-rearranged Spindle Cell Neoplasm of the Lung: A Clinicopathologic and Molecular Analysis of 3 Cases. | 0 |
| 26863915 | 2016 | Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. | 0 |
| 31792356 | 2020 | NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas-a study of 4569 cases. | 0 |
| 32050835 | 2020 | Myxoid Spindle Cell Sarcoma With LMNA-NTRK Fusion: Expanding the Morphologic Spectrum of NTRK-Rearranged Tumors. | 0 |
| 31631147 | 2019 | [A Case of Pediatric Soft Tissue Sarcoma with LMNA-NTRK1 Gene Fusion Treated with Larotrectinib under Single Patient Expanded Access System]. | 0 |
| 38825906 | 2024 | [Clinicopathological and molecular characteristics of NTRK-rearranged spindle cell neoplasms in the gastrointestinal tract]. | 0 |
| 29421787 | 2018 | A de novo 1q22q23.1 Interstitial Microdeletion in a Girl with Intellectual Disability and Multiple Congenital Anomalies Including Congenital Heart Defect. | 0 |
Bibliography
| Pubmed ID | Publication Year | Title | Authors |
|---|---|---|---|
| 30709876 | 2019 | Refractory and metastatic infantile fibrosarcoma harboring LMNA-NTRK1 fusion shows complete and durable response to crizotinib. | Bender J, et al |
| 27259011 | 2016 | Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors. | Agaram NP, et al |
| 32519338 | 2021 | LMNA-NTRK1 rearranged mesenchymal tumor (lipofibromatosis-like neural tumor) mimicking pigmented dermatofibrosarcoma protuberans. | Panse G, et al |
| 30134855 | 2018 | A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report. | Zhou N, et al |
