del(6)(q23q26) MYB::QKI

Genes involved

MYB (6q23.3)

QKI (6q26)

Oncogenic mechanisms

MYB overexpression and the loss-of-function of QKI

Tumor type

Angiocentric glioma

Highly cited references

Pubmed IDYearTitleCitations
247677142014Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors.83
268297512016MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.76
268100702016Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.67
381952202025Clinicopathological analysis of BRAF and non-BRAF MAPK pathway-altered gliomas in paediatric and adult patients: a single-institution study of 40 patients.59
281047172017Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.43
390988572025Clinical characteristics and detection of MYB-QKI fusions in patients with angiocentric glioma.37
365924152023MYB/MYBL1::QKI fusion-positive diffuse glioma.22
373622452023Case Report: Brainstem angiocentric glioma presenting in a toddler child-diagnostic and therapeutic challenges.21
384660862024Comprehensive analysis of MYB/MYBL1-altered pediatric-type diffuse low-grade glioma.19
371651212023DIPG-like MYB-altered diffuse astrocytoma with durable response to intensive chemotherapy.19
287760912017Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex.8
279739812017MYB-QKI drives childhood brain tumors via tripartite mechanism.7
288033982017Brainstem angiocentric gliomas with MYB-QKI rearrangements.5
325891282020MYB-QKI rearrangement in angiocentric glioma.0
395697422024MYB::QKI fusion-positive diffuse glioma of the cerebellum: A case report.0
348634342021Angiocentric glioma: A case report and review of the literature.0
327321472021[Low grade glioma with MYBL1 alteration: Case report of an uncommon pediatric neoplasm].0

Bibliography

Pubmed IDPublication YearTitleAuthors
279739812017MYB-QKI drives childhood brain tumors via tripartite mechanism.Jain P, et al
288033982017Brainstem angiocentric gliomas with MYB-QKI rearrangements.D'Aronco L, et al
335686532021A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement.Zhang Y, et al
268297512016MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.Bandopadhayay P, et al
287760912017Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex.Chan E, et al