HRAS (Harvey rat sarcoma viral oncogene homolog)

1999-02-01 Franz Watzinger , Thomas Lion Affiliation

Childrens Cancer Research Institute (CCRI), Kinderspitalgasse 6, A-1090 Vienna, Austria

Identity

HGNC

HRAS

LOCATION

11p15.5

IMAGE

LEGEND

Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics

LOCUSID

3265

ALIAS

C-BAS/HAS,C-H-RAS,C-HA-RAS1,CTLO,H-RASIDX,HAMSV,HRAS1,RASH1,p21ras

FUSION GENES

Show Gene Fusions

DNA/RNA

H-ras splicing variants :

alternative splicing of H-ras precursor mRNA leads to the two transcripts p19 and p21 which differ by the ex- or inclusion of the Intron D Exon (IDX); Exons that encode protein are shown as black boxes, untranslated exons as white boxes; the upstream untranslated exon is indicated as Exon -1

Description

consists of six exons, spread over 6.6kb of genomic DNA

Transcription

alternative RNA splicing reveals two different transcripts (see Fig); if the Intron D Exon (IDX) is skipped exon 4 is directly joined to exon 3

Note

to be quoted is the existence of a pseudogene, c-Ha-ras 2, inactivated, processed pseudogene which is located on Chromosome X.

Proteins

Entity

p21H-ras

Description

regular RAS protein - characterized in the RAS family page

Expression

ubiquitously expressed

Localisation

anchored to the inner surface of the plasma membrane

Function

analogously to other GTP-binding proteins (such as Translation Elongation Factor EFTu or signal transducing G-Proteins) RAS proteins are involved in signal transduction pathways

Homology

ras gene family is part of the ras superfamily including the mammalian RAS, RAL, RAC, RHO, RAP, and RAB gene families and the yeast homologs like SEC4 and YPT1 genes; genes encode small monomeric proteins of low molecular mass (20-30 kDa) which share at least 30% homology with RAS proteins.

Implicated in

Entity name

tumor (frequency of H-RAS mutations); references in Full Bibliography

Entity name

stomach (0-40%)

Entity name

urinary bladder (0-65%)

Entity name

prostate (0-10%)

Entity name

skin (0-45%)

Entity name

thyroid (0-60%)

Entity name

breast (0-10%)

Entity name

head and neck (0-30%)

Entity name

endometrium (5%)

Article Bibliography

Pubmed ID	Last Year	Title	Authors
2114981	1990	ras oncogenes: their role in neoplasia.	Barbacid M et al
2547513	1989	ras oncogenes in human cancer: a review.	Bos JL et al
9724079	1998	Variability of Ha-ras (codon 12) proto-oncogene mutations in diverse thyroid cancers.	Bouras M et al
8096149	1993	Codon 12 Harvey-ras mutations are rare events in non-melanoma human skin cancer.	Campbell C et al
8919545	1996	Ras oncogene mutations in thyroid tumors: polymerase chain reaction-restriction-fragment-length polymorphism analysis from paraffin-embedded tissues.	Capella G et al
2208148	1990	ras gene mutations in human prostate cancer.	Carter BS et al
8353052	1993	The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.	Clark LJ et al
2667764	1989	Expression of the H-ras proto-oncogene is controlled by alternative splicing.	Cohen JB et al
1671796	1991	Correlation of mutations of oncogene C-Ha-ras at codon 12 with metastasis and survival of gastric cancer patients.	Deng GR et al
3600795	1987	A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases.	Fusco A et al
1998954	1991	Activated ras alleles in human carcinoma of the prostate are rare.	Gumerlock PH et al
9048488	1996	A PCR-RFLP method for the detection of activated H-ras oncogene with a point mutation at codon 12 and 61.	Hong SJ et al
9261359	1997	A splicing enhancer in the 3'-terminal c-H-ras exon influences mRNA abundance and transforming activity.	Hwang DY et al
7599040	1995	Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.	Kiaris H et al
9137494	1997	Mutation of ras oncogene in gastric adenocarcinoma: association with histological phenotype.	Kim TY et al
9018336	1997	Comparison of ras activation in prostate carcinoma in Japanese and American men.	Konishi N et al
6089200	1984	A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.	Kraus MH et al
2648253	1989	High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.	Lemoine NR et al
4084726	1985	Oncogenes and bladder cancer.	Malone PR et al
1421167	1992	ras activation in experimental carcinogenesis.	Mangues R et al
2049776	1991	K-ras activation in gastric epithelial tumors in Japanese.	Miki H et al
2179035	1990	Infrequent point mutations of ras oncogenes in gastric cancers.	Nanus DM et al
3307760	1987	Human cancer and cellular oncogenes.	Nishimura S et al
9703927	1998	Low-frequency mutation of Ha-ras and Ki-ras oncogenes in transitional cell carcinoma of the bladder.	Olderøy G et al
2183872	1990	Low incidence of ras oncogene activation in human squamous cell carcinomas.	Rumsby G et al
9179693	1997	Screening of H-ras gene point mutations in 50 cases of bladder carcinoma.	Saito S et al
2021541	1991	High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.	Saranath D et al
9713462	1998	Mutations of ras genes are relatively frequent in Japanese prostate cancers: pointing to genetic differences between populations.	Shiraishi T et al
3435051	1987	Oncogene activation in malignant transformation: a study of H-ras in human breast cancer.	Spandidos DA et al
3283656	1988	Detection of activated ras oncogenes in human thyroid carcinomas.	Suárez HG et al
1501884	1992	Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer.	Törmänen VT et al
8960147	1996	ras gene mutations in human endometrial carcinoma.	Varras MN et al
2199031	1990	No evidence for point mutations in codons 12, 13, and 61 of the ras gene in a high-incidence area for esophageal and gastric cancers.	Victor T et al
3144694	1988	Preferential and novel activation of H-ras in human bladder carcinomas.	Visvanathan KV et al

Other Information

Locus ID:

NCBI: 3265
MIM: 190020
HGNC: 5173
Ensembl: ENSG00000174775

Variants:

dbSNP: 3265
ClinVar: 3265
TCGA: ENSG00000174775
COSMIC: HRAS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174775	ENST00000311189	P01112
ENSG00000174775	ENST00000311189	X5D945
ENSG00000174775	ENST00000397594	P01112
ENSG00000174775	ENST00000397596	P01112
ENSG00000174775	ENST00000397596	X5D945
ENSG00000174775	ENST00000417302	P01112
ENSG00000174775	ENST00000451590	P01112
ENSG00000174775	ENST00000451590	X5D945
ENSG00000174775	ENST00000493230	P01112

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
ErbB signaling pathway	KEGG	ko04012
Autophagy - animal	KEGG	ko04140
mTOR signaling pathway	KEGG	ko04150
Apoptosis	KEGG	ko04210
Axon guidance	KEGG	ko04360
VEGF signaling pathway	KEGG	ko04370
Focal adhesion	KEGG	ko04510
Gap junction	KEGG	ko04540
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
B cell receptor signaling pathway	KEGG	ko04662
Fc epsilon RI signaling pathway	KEGG	ko04664
Long-term potentiation	KEGG	ko04720
Long-term depression	KEGG	ko04730
Regulation of actin cytoskeleton	KEGG	ko04810
Insulin signaling pathway	KEGG	ko04910
GnRH signaling pathway	KEGG	ko04912
Melanogenesis	KEGG	ko04916
Renal cell carcinoma	KEGG	ko05211
Endometrial cancer	KEGG	ko05213
Glioma	KEGG	ko05214
Prostate cancer	KEGG	ko05215
Thyroid cancer	KEGG	ko05216
Melanoma	KEGG	ko05218
Bladder cancer	KEGG	ko05219
Chronic myeloid leukemia	KEGG	ko05220
Acute myeloid leukemia	KEGG	ko05221
Non-small cell lung cancer	KEGG	ko05223
MAPK signaling pathway	KEGG	hsa04010
ErbB signaling pathway	KEGG	hsa04012
Autophagy - animal	KEGG	hsa04140
mTOR signaling pathway	KEGG	hsa04150
Apoptosis	KEGG	hsa04210
Axon guidance	KEGG	hsa04360
VEGF signaling pathway	KEGG	hsa04370
Focal adhesion	KEGG	hsa04510
Gap junction	KEGG	hsa04540
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
B cell receptor signaling pathway	KEGG	hsa04662
Fc epsilon RI signaling pathway	KEGG	hsa04664
Long-term potentiation	KEGG	hsa04720
Long-term depression	KEGG	hsa04730
Regulation of actin cytoskeleton	KEGG	hsa04810
Insulin signaling pathway	KEGG	hsa04910
GnRH signaling pathway	KEGG	hsa04912
Melanogenesis	KEGG	hsa04916
Pathways in cancer	KEGG	hsa05200
Renal cell carcinoma	KEGG	hsa05211
Endometrial cancer	KEGG	hsa05213
Glioma	KEGG	hsa05214
Prostate cancer	KEGG	hsa05215
Thyroid cancer	KEGG	hsa05216
Melanoma	KEGG	hsa05218
Bladder cancer	KEGG	hsa05219
Chronic myeloid leukemia	KEGG	hsa05220
Acute myeloid leukemia	KEGG	hsa05221
Non-small cell lung cancer	KEGG	hsa05223
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Cholinergic synapse	KEGG	hsa04725
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Serotonergic synapse	KEGG	hsa04726
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hepatitis B	KEGG	hsa05161
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
FoxO signaling pathway	KEGG	hsa04068
Thyroid hormone signaling pathway	KEGG	hsa04919
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
Central carbon metabolism in cancer	KEGG	hsa05230
Choline metabolism in cancer	KEGG	hsa05231
Central carbon metabolism in cancer	KEGG	ko05230
Choline metabolism in cancer	KEGG	ko05231
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Post NMDA receptor activation events	REACTOME	R-HSA-438064
CREB phosphorylation through the activation of Ras	REACTOME	R-HSA-442742
Ras activation uopn Ca2+ infux through NMDA receptor	REACTOME	R-HSA-442982
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by EGFR in Cancer	REACTOME	R-HSA-1643713
Signaling by Ligand-Responsive EGFR Variants in Cancer	REACTOME	R-HSA-5637815
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	REACTOME	R-HSA-1236382
Signaling by EGFRvIII in Cancer	REACTOME	R-HSA-5637812
Constitutive Signaling by EGFRvIII	REACTOME	R-HSA-5637810
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR1 in disease	REACTOME	R-HSA-5655302
Signaling by FGFR2 in disease	REACTOME	R-HSA-5655253
Signaling by FGFR3 in disease	REACTOME	R-HSA-5655332
Signaling by FGFR4 in disease	REACTOME	R-HSA-5655291
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
Activation of RAS in B cells	REACTOME	R-HSA-1169092
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
RAF activation	REACTOME	R-HSA-5673000
MAP2K and MAPK activation	REACTOME	R-HSA-5674135
Negative regulation of MAPK pathway	REACTOME	R-HSA-5675221
Regulation of RAS by GAPs	REACTOME	R-HSA-5658442
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CD209 (DC-SIGN) signaling	REACTOME	R-HSA-5621575
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Tie2 Signaling	REACTOME	R-HSA-210993
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR1	REACTOME	R-HSA-5654736
Downstream signaling of activated FGFR1	REACTOME	R-HSA-5654687
FRS-mediated FGFR1 signaling	REACTOME	R-HSA-5654693
SHC-mediated cascade:FGFR1	REACTOME	R-HSA-5654688
Signaling by FGFR2	REACTOME	R-HSA-5654738
Downstream signaling of activated FGFR2	REACTOME	R-HSA-5654696
FRS-mediated FGFR2 signaling	REACTOME	R-HSA-5654700
SHC-mediated cascade:FGFR2	REACTOME	R-HSA-5654699
Signaling by FGFR3	REACTOME	R-HSA-5654741
Downstream signaling of activated FGFR3	REACTOME	R-HSA-5654708
FRS-mediated FGFR3 signaling	REACTOME	R-HSA-5654706
SHC-mediated cascade:FGFR3	REACTOME	R-HSA-5654704
Signaling by FGFR4	REACTOME	R-HSA-5654743
Downstream signaling of activated FGFR4	REACTOME	R-HSA-5654716
FRS-mediated FGFR4 signaling	REACTOME	R-HSA-5654712
SHC-mediated cascade:FGFR4	REACTOME	R-HSA-5654719
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
p38MAPK events	REACTOME	R-HSA-171007
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by ERBB2	REACTOME	R-HSA-1227986
SHC1 events in ERBB2 signaling	REACTOME	R-HSA-1250196
GRB2 events in ERBB2 signaling	REACTOME	R-HSA-1963640
Signaling by ERBB4	REACTOME	R-HSA-1236394
SHC1 events in ERBB4 signaling	REACTOME	R-HSA-1250347
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
EGFR Transactivation by Gastrin	REACTOME	R-HSA-2179392
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
SHC-related events triggered by IGF1R	REACTOME	R-HSA-2428933
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
EPH-Ephrin signaling	REACTOME	R-HSA-2682334
EPHB-mediated forward signaling	REACTOME	R-HSA-3928662
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Signaling by PTK6	REACTOME	R-HSA-8848021
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	REACTOME	R-HSA-8849471
Signaling by FGFR3 point mutants in cancer	REACTOME	R-HSA-8853338
Signaling by FGFR3 fusions in cancer	REACTOME	R-HSA-8853334
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
Endocrine resistance	KEGG	ko01522
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
Endocrine resistance	KEGG	hsa01522
RET signaling	REACTOME	R-HSA-8853659
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224
Oncogenic MAPK signaling	REACTOME	R-HSA-6802957
Signaling by RAS mutants	REACTOME	R-HSA-6802949
Signaling by high-kinase activity BRAF mutants	REACTOME	R-HSA-6802948
Signaling by moderate kinase activity BRAF mutants	REACTOME	R-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAF	REACTOME	R-HSA-6802955
Signaling by BRAF and RAF fusions	REACTOME	R-HSA-6802952
RAS signaling downstream of NF1 loss-of-function variants	REACTOME	R-HSA-6802953
Signaling by MET	REACTOME	R-HSA-6806834
MET activates RAS signaling	REACTOME	R-HSA-8851805
Apelin signaling pathway	KEGG	hsa04371
Mitophagy - animal	KEGG	ko04137
Mitophagy - animal	KEGG	hsa04137

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA165946873	vemurafenib	Chemical	LabelAnnotation	associated
PA166114911	dabrafenib	Chemical	LabelAnnotation	associated
PA166115364	trametinib	Chemical	LabelAnnotation	associated
PA24928	ARAF	Gene	Pathway	associated
PA25408	BRAF	Gene	Pathway	associated	28362716
PA26880	CRK	Gene	Pathway	associated	20124951
PA28127	FGFR1	Gene	Pathway	associated	28362716
PA28180	FLT1	Gene	Pathway	associated	28362716
PA28181	FLT3	Gene	Pathway	associated	28362716
PA28183	FLT4	Gene	Pathway	associated	28362716
PA30086	KDR	Gene	Pathway	associated	28362716
PA30128	KIT	Gene	Pathway	associated	28362716
PA30592	MAP3K1	Gene	Pathway	associated
PA33148	PDGFRB	Gene	Pathway	associated	28362716
PA34183	RAF1	Gene	Pathway	associated	20124951, 28362716
PA34335	RET	Gene	Pathway	associated	28362716
PA446108	Colorectal Neoplasms	Disease	MultilinkAnnotation	associated	26237292
PA7360	EGFR	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
38502412	2024	Unraveling the Genetic Web: H-Ras Expression and Mutation in Oral Squamous Cell Carcinoma-A Systematic Review.	0
38757223	2024	Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice.	0
38502412	2024	Unraveling the Genetic Web: H-Ras Expression and Mutation in Oral Squamous Cell Carcinoma-A Systematic Review.	0
38757223	2024	Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice.	0
35981076	2023	Cutaneous manifestations in Costello syndrome: HRAS p.Gly12Ser affects RIN1-mediated integrin trafficking in immortalized epidermal keratinocytes.	1
36480093	2023	A Subset of Salivary Intercalated Duct Lesions Harbors Recurrent CTNNB1 and HRAS Mutations: A Molecular Link to Basal Cell Adenoma and Epithelial-Myoepithelial Carcinoma?	1
36753744	2023	Mutated HRAS Activates YAP1-AXL Signaling to Drive Metastasis of Head and Neck Cancer.	3
36995904	2023	Crystal Structure of an i-Motif from the HRAS Oncogene Promoter.	1
37013448	2023	RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.	0
37192201	2023	Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1.	0
37194190	2023	A very mild phenotype in six individuals of a three-generation family with the novel HRAS variant c.176C > G p.(Ala59Gly): Emergence of a new HRAS-related RASopathy distinct from Costello syndrome.	0
37665491	2023	Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma.	2
37820992	2023	ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21(HRAS) splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade.	0
35981076	2023	Cutaneous manifestations in Costello syndrome: HRAS p.Gly12Ser affects RIN1-mediated integrin trafficking in immortalized epidermal keratinocytes.	1
36480093	2023	A Subset of Salivary Intercalated Duct Lesions Harbors Recurrent CTNNB1 and HRAS Mutations: A Molecular Link to Basal Cell Adenoma and Epithelial-Myoepithelial Carcinoma?	1

Citation

Franz Watzinger ; Thomas Lion

HRAS (Harvey rat sarcoma viral oncogene homolog)

Atlas Genet Cytogenet Oncol Haematol. 1999-02-01

Online version: http://atlasgeneticsoncology.org/gene/108/favicon/teaching-explorer/meetings/