MVP (major vault protein)

MVP (major vault protein)

2000-05-01 Franck Vigué Affiliation

Laboratoire de Cytogenetique - Service dHematologie Biologique, Hopital Hotel-Dieu - 75181 Paris Cedex 04, France

Identity

HGNC

LOCATION

16p11.2

LOCUSID

ALIAS

LRP,VAULT1

FUSION GENES

Show Gene Fusions

DNA/RNA

Transcription

coding sequence, corresponding to full mRNA, is 2840 bp long

Proteins

Description

110 KD protein, 896 amino acids; major cytoplasmic vault protein; vaults are nucleoproteic complexes composed of the MVP associated with two high-molecular weight proteins p240 and p193 which surround a small 140 nucleotides RNA species

Expression

expressed in a variety of human tumor cell lines, the major part being multidrug resistant; expressed also in primary solid tumors, mainly colon carcinoma or ovarian carcinoma, as well as in hematopoietic cancers (myelodysplastic syndrome, acute myeloid or lymphoid leukemia, multiple myeloma); in normal tissues, LRP expression has a wide distribution, with particularly high levels in epithelial cells of the digestive tract

Localisation

cytoplasmic, in the cytosol, with a little fraction (approximately 5%) located in the nuclear membrane and nuclear pores

Function

vault are cytoplasmic organelles which mediate bidirectional nucleocytoplasmic transport of a wide range of substrates, including cytotoxic drugs; vaults would be involved both in vesicule and cytosolic transport of molecules

Homology

104 kD rat MVP

Implicated in

Entity name

implicated in induced multidrug-resistance to anticancer chemotherapy

Disease

it includes resistance to doxorubicin, vinca alkaloids, mitoxantrone and etoposide; the role of LRP by itself in multidrug-resistance is not completely clear because it is only a part of a nucleo-proteic complex involved in macromolecules transport; the introduction and expression of the LRP gene in cells by transfection does not confer a multidrug-resistance phenotype; overexpression of LRP has been associated with poor response to chemotherapy in various types of leukemia and in ovarian carcinoma, however the role of LRP as pronostic factor remains controversial; in multi-resistant cell lines, LRP amplification within a homogeneous staining region is exceptional

Bibliography

Pubmed ID	Last Year	Title	Authors

Other Information

Locus ID:

NCBI: 9961
MIM: 605088
HGNC: 7531
Ensembl: ENSG00000013364

Variants:

dbSNP: 9961
ClinVar: 9961
TCGA: ENSG00000013364
COSMIC: MVP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000013364	ENST00000357402	Q14764
ENSG00000013364	ENST00000357402	X5D2M8
ENSG00000013364	ENST00000395353	Q14764
ENSG00000013364	ENST00000395353	X5D2M8
ENSG00000013364	ENST00000562463	H3BUP3
ENSG00000013364	ENST00000563123	I3L155
ENSG00000013364	ENST00000563558	H3BNF6
ENSG00000013364	ENST00000563915	H3BQK6
ENSG00000013364	ENST00000565164	H3BNF2
ENSG00000013364	ENST00000566066	H3BP76
ENSG00000013364	ENST00000566252	H3BUK7
ENSG00000013364	ENST00000566859	H3BQE7
ENSG00000013364	ENST00000569887	H3BPZ2
ENSG00000013364	ENST00000570234	H3BRL2
ENSG00000013364	ENST00000629059	H3BPZ2

Expression (GTEx)

0

50

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
28211508	2017	MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.	77
21829365	2011	Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy.	72
12576456	2003	RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.	69
15133037	2004	The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.	50
17615361	2007	Host resistance to lung infection mediated by major vault protein in epithelial cells.	41
12177006	2002	PTEN associates with the vault particles in HeLa cells.	37
11986944	2002	Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML).	34
17875533	2007	Expression of multidrug resistance 1 (MDR1), multidrug resistance-related protein 1 (MRP1), lung resistance protein (LRP), and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia.	27
17178862	2006	Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein.	26
19875192	2010	Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy.	20

Citation

Franck Vigué

MVP (major vault protein)

Atlas Genet Cytogenet Oncol Haematol. 2000-05-01

Online version: http://atlasgeneticsoncology.org/gene/120/css/lib/js/lib/jquery-3.5.1.min.js