MVP (major vault protein)

MVP (major vault protein)

2000-05-01 Franck Vigué Affiliation

Laboratoire de Cytogenetique - Service dHematologie Biologique, Hopital Hotel-Dieu - 75181 Paris Cedex 04, France

Identity

HGNC

LOCATION

16p11.2

LOCUSID

ALIAS

LRP,VAULT1

FUSION GENES

Show Gene Fusions

DNA/RNA

Transcription

coding sequence, corresponding to full mRNA, is 2840 bp long

Proteins

Description

110 KD protein, 896 amino acids; major cytoplasmic vault protein; vaults are nucleoproteic complexes composed of the MVP associated with two high-molecular weight proteins p240 and p193 which surround a small 140 nucleotides RNA species

Expression

expressed in a variety of human tumor cell lines, the major part being multidrug resistant; expressed also in primary solid tumors, mainly colon carcinoma or ovarian carcinoma, as well as in hematopoietic cancers (myelodysplastic syndrome, acute myeloid or lymphoid leukemia, multiple myeloma); in normal tissues, LRP expression has a wide distribution, with particularly high levels in epithelial cells of the digestive tract

Localisation

cytoplasmic, in the cytosol, with a little fraction (approximately 5%) located in the nuclear membrane and nuclear pores

Function

vault are cytoplasmic organelles which mediate bidirectional nucleocytoplasmic transport of a wide range of substrates, including cytotoxic drugs; vaults would be involved both in vesicule and cytosolic transport of molecules

Homology

104 kD rat MVP

Implicated in

Entity name

implicated in induced multidrug-resistance to anticancer chemotherapy

Disease

it includes resistance to doxorubicin, vinca alkaloids, mitoxantrone and etoposide; the role of LRP by itself in multidrug-resistance is not completely clear because it is only a part of a nucleo-proteic complex involved in macromolecules transport; the introduction and expression of the LRP gene in cells by transfection does not confer a multidrug-resistance phenotype; overexpression of LRP has been associated with poor response to chemotherapy in various types of leukemia and in ovarian carcinoma, however the role of LRP as pronostic factor remains controversial; in multi-resistant cell lines, LRP amplification within a homogeneous staining region is exceptional

Bibliography

Pubmed ID	Last Year	Title	Authors
10651723	2000	P-glycoprotein and multidrug resistance-associated protein, but not lung resistance protein, lower the intracellular daunorubicin accumulation in acute myeloid leukaemic cells.	Borg AG et al
9713498	1998	Coexpression of multidrug resistance involve proteins: a flow cytometric analysis.	Boutonnat J et al
1360704	1992	Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.	Cole SP et al
9592977	1998	P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias.	Damiani D et al
10499614	1999	Expression of the lung resistance protein predicts poor outcome in patients with multiple myeloma.	Filipits M et al
9357965	1997	Expression of the human major vault protein LRP in acute myeloid leukemia.	Hart SM et al
8763338	1996	Major vault protein LRP-related multidrug resistance.	Izquierdo MA et al
9378536	1997	Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines.	Laurençot CM et al
9747635	1998	Multidrug resistance in leukemia.	Leith C et al
9643568	1998	Expression of lung resistance protein and correlation with other drug resistance proteins and outcome in myelodysplastic syndromes.	Lepelley P et al
10562814	1999	Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis.	Meijer GA et al
10697509	1999	Expression of the lung resistance protein (LRP) in primary breast cancer.	Pohl G et al
9446666	1998	Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma.	Raaijmakers HG et al
7671223	1995	The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification.	Slovak ML et al
9713485	1998	Multidrug resistance and its reversal.	Volm M et al
9490695	1998	Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia.	den Boer ML et al

Other Information

Locus ID:

NCBI: 9961
MIM: 605088
HGNC: 7531
Ensembl: ENSG00000013364

Variants:

dbSNP: 9961
ClinVar: 9961
TCGA: ENSG00000013364
COSMIC: MVP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000013364	ENST00000357402	Q14764
ENSG00000013364	ENST00000357402	X5D2M8
ENSG00000013364	ENST00000395353	Q14764
ENSG00000013364	ENST00000395353	X5D2M8
ENSG00000013364	ENST00000562463	H3BUP3
ENSG00000013364	ENST00000563123	I3L155
ENSG00000013364	ENST00000563558	H3BNF6
ENSG00000013364	ENST00000563915	H3BQK6
ENSG00000013364	ENST00000565164	H3BNF2
ENSG00000013364	ENST00000566066	H3BP76
ENSG00000013364	ENST00000566252	H3BUK7
ENSG00000013364	ENST00000566859	H3BQE7
ENSG00000013364	ENST00000569887	H3BPZ2
ENSG00000013364	ENST00000570234	H3BRL2
ENSG00000013364	ENST00000629059	H3BPZ2

Expression (GTEx)

0

50

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38264642	2023	Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.	1
38264642	2023	Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.	1
32894437	2021	Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP).	7
33609362	2021	Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.	9
33637972	2021	Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade.	10
34829999	2021	MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.	4
32894437	2021	Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP).	7
33609362	2021	Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.	9
33637972	2021	Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade.	10
34829999	2021	MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.	4
30082909	2019	Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation.	45
30336197	2019	Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells.	30
30654824	2019	Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP).	59
30674943	2019	Lung resistance-related protein (LRP) predicts favorable therapeutic outcome in Acute Myeloid Leukemia.	4
30996248	2019	Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.	42

Citation

Franck Vigué

MVP (major vault protein)

Atlas Genet Cytogenet Oncol Haematol. 2000-05-01

Online version: http://atlasgeneticsoncology.org/gene/120/teaching-explorer/gene-fusions-explorer/js/lib/zoomerang.js