CDKN2C (cyclin dependent kinase inhibitor 2C)

2003-02-01  

Identity

HGNC
CDKN2C
LOCATION
1p32.3
LOCUSID
1031
ALIAS
INK4C,p18,p18-INK4C

Other Information

Locus ID:

NCBI: 1031
MIM: 603369
HGNC: 1789
Ensembl: ENSG00000123080

Variants:

dbSNP: 1031
ClinVar: 1031
TCGA: ENSG00000123080
COSMIC: CDKN2C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123080ENST00000262662P42773
ENSG00000123080ENST00000262662Q6ICV4
ENSG00000123080ENST00000371761P42773
ENSG00000123080ENST00000371761Q6ICV4
ENSG00000123080ENST00000396148P42773
ENSG00000123080ENST00000396148Q6ICV4

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363342462023Novel germline variants of CDKN1B and CDKN2C identified during screening for familial primary hyperparathyroidism.3
372238542023The Oncogenic Role of Cyclin-Dependent Kinase Inhibitor 2C in Lower-Grade Glioma.1
373454322023p18INK4C and BRCA1 inhibit follicular cell proliferation and dedifferentiation in thyroid cancer.0
377337532023CBX8 promotes lung adenocarcinoma growth and metastasis through transcriptional repression of CDKN2C and SCEL.2
363342462023Novel germline variants of CDKN1B and CDKN2C identified during screening for familial primary hyperparathyroidism.3
372238542023The Oncogenic Role of Cyclin-Dependent Kinase Inhibitor 2C in Lower-Grade Glioma.1
373454322023p18INK4C and BRCA1 inhibit follicular cell proliferation and dedifferentiation in thyroid cancer.0
377337532023CBX8 promotes lung adenocarcinoma growth and metastasis through transcriptional repression of CDKN2C and SCEL.2
348962532022CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?4
348962532022CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?4
340769872021Downregulated miRNA-22-3p promotes the progression and leads to poor prognosis of hepatocellular carcinoma through targeting CDKN2C.6
349072312021The distinct effects of P18 overexpression on different stages of hematopoiesis involve TGF-β and NF-κB signaling.0
340769872021Downregulated miRNA-22-3p promotes the progression and leads to poor prognosis of hepatocellular carcinoma through targeting CDKN2C.6
349072312021The distinct effects of P18 overexpression on different stages of hematopoiesis involve TGF-β and NF-κB signaling.0
320904902020miR-21-5p promotes cell proliferation and G1/S transition in melanoma by targeting CDKN2C.16

Citation

Dessen P

CDKN2C (cyclin dependent kinase inhibitor 2C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/190/tumors-explorer/case-report-explorer/