STARD3 (START domain containing 3)
2000-03-01 Marie-Christine Rio AffiliationI.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France
Identity
HGNC
LOCATION
17q12
LOCUSID
ALIAS
CAB1,MLN64,es64
FUSION GENES
DNA/RNA
Transcription
cDNA: 2.1 kb; coding sequence: 1335 bp
Proteins
Description
445 amino acids; 50 kDa; contains four putative transmembrane domains at its N-terminal part; posseses a StAR Homology Domain at its C-terminal part
Homology
with StAR (Steroidogenic Acute Regulatory protein)
Implicated in
Entity name
breast carcinomas
Disease
17q11-q21 amplification is found in about 25% of primary breast carcinomas
Prognosis
poor clinical outcome; increase risk of relapse
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9270027 | 1997 | Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method. | Akiyama N et al |
| 8752152 | 1996 | Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer. | Bièche I et al |
| 9139840 | 1997 | MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomas. | Moog-Lutz C et al |
| 7490069 | 1995 | Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. | Tomasetto C et al |
| 9237999 | 1997 | MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis. | Watari H et al |
Other Information
Locus ID:
NCBI: 10948
MIM: 607048
HGNC: 17579
Ensembl: ENSG00000131748
Variants:
dbSNP: 10948
ClinVar: 10948
TCGA: ENSG00000131748
COSMIC: STARD3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38151289 | 2024 | Metastatic Lymph Node 64 (MLN64) Expression in Gastric Cancer: The Clinical and Molecular Implications in Drug Resistance. | 0 |
| 38151289 | 2024 | Metastatic Lymph Node 64 (MLN64) Expression in Gastric Cancer: The Clinical and Molecular Implications in Drug Resistance. | 0 |
| 37245582 | 2023 | The ultrastructural function of MLN64 in the late endosome-mitochondria membrane contact sites in placental cells. | 1 |
| 37507014 | 2023 | Methionine sulfoxide reductases and cholesterol transporter STARD3 constitute an efficient system for detoxification of cholesterol hydroperoxides. | 1 |
| 37245582 | 2023 | The ultrastructural function of MLN64 in the late endosome-mitochondria membrane contact sites in placental cells. | 1 |
| 37507014 | 2023 | Methionine sulfoxide reductases and cholesterol transporter STARD3 constitute an efficient system for detoxification of cholesterol hydroperoxides. | 1 |
| 35022465 | 2022 | Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions. | 7 |
| 35022465 | 2022 | Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions. | 7 |
| 28282615 | 2017 | MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content. | 30 |
| 28377464 | 2017 | STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites. | 115 |
| 28282615 | 2017 | MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content. | 30 |
| 28377464 | 2017 | STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites. | 115 |
| 27055092 | 2016 | Homozygous Mutation of the FGFR1 Gene Associated with Congenital Heart Disease and 46,XY Disorder of Sex Development. | 3 |
| 27068960 | 2016 | Touché! STARD3 and STARD3NL tether the ER to endosomes. | 12 |
| 27487925 | 2016 | Structure of the lutein-binding domain of human StARD3 at 1.74 Å resolution and model of a complex with lutein. | 23 |
Citation
Marie-Christine Rio
STARD3 (START domain containing 3)
Atlas Genet Cytogenet Oncol Haematol. 2000-03-01
Online version: http://atlasgeneticsoncology.org/gene/202/stard3
