TP73 (tumor protein p73)

2003-02-01  

Identity

HGNC
TP73
LOCATION
1p36.32
LOCUSID
7161
ALIAS
P73
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7161
MIM: 601990
HGNC: 12003
Ensembl: ENSG00000078900

Variants:

dbSNP: 7161
ClinVar: 7161
TCGA: ENSG00000078900
COSMIC: TP73

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078900ENST00000346387O15350
ENSG00000078900ENST00000354437O15350
ENSG00000078900ENST00000357733O15350
ENSG00000078900ENST00000378280A0A0C4DFW9
ENSG00000078900ENST00000378285O15350
ENSG00000078900ENST00000378288O15350
ENSG00000078900ENST00000378290O15350
ENSG00000078900ENST00000378295O15350
ENSG00000078900ENST00000378295A0A024R4C3
ENSG00000078900ENST00000603362O15350
ENSG00000078900ENST00000604074O15350
ENSG00000078900ENST00000604479O15350

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of PUMA and translocation to mitochondriaREACTOMER-HSA-139915
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Death Receptors and LigandsREACTOMER-HSA-6803211
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseREACTOMER-HSA-6803204
TP53 Regulates Transcription of Caspase Activators and CaspasesREACTOMER-HSA-6803207
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainREACTOMER-HSA-6803205
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through Association with Co-factorsREACTOMER-HSA-6804759

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379310772024Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.2
384155542024Lack of Association between TP73 G4C14-A4T14 Polymorphism and Cervical Cancer Risk in Overall and Asian Women: A Meta-Analysis.1
387398022024Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73.1
379310772024Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.2
384155542024Lack of Association between TP73 G4C14-A4T14 Polymorphism and Cervical Cancer Risk in Overall and Asian Women: A Meta-Analysis.1
387398022024Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73.1
366562672023STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis.1
378641232023Clinical landscape of TP73 structural variants in ATL patients.0
366562672023STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis.1
378641232023Clinical landscape of TP73 structural variants in ATL patients.0
343808472022Association of p73 G4C14-A4T14 and p53 codon 72 polymorphism with cervical cancer in Chinese population.0
344945062022Effects of HRG and TP73 gene variations on ovarian response.1
348973402022Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of TP73.4
349697582022Eupatilin Suppresses Pancreatic Cancer Cells via Glucose Uptake Inhibition, AMPK Activation, and Cell Cycle Arrest.2
350202422022Rare variants in TP73 in a frontotemporal dementia cohort link this gene with primary progressive aphasia phenotypes.2

Citation

Dessen P

TP73 (tumor protein p73)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/205/css/case-report-explorer/css/card-gene.css