Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1111
MIM: 603078
HGNC: 1925
Ensembl: ENSG00000149554
Variants:
dbSNP: 1111
ClinVar: 1111
TCGA: ENSG00000149554
COSMIC: CHEK1
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA61 | ATM | Gene | Pathway | associated | |||
| PA74 | ATR | Gene | Pathway | associated | |||
| PA95 | CCNB1 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38047473 | 2024 | In silico and structure-based evaluation of deleterious mutations identified in human Chk1, Chk2, and Wee1 protein kinase. | 0 |
| 38266782 | 2024 | OTUB1 Targets CHK1 for Deubiquitination and Stabilization to Facilitate Lung Cancer Progression and Radioresistance. | 0 |
| 38578830 | 2024 | Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates. | 0 |
| 38588804 | 2024 | The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction. | 0 |
| 38047473 | 2024 | In silico and structure-based evaluation of deleterious mutations identified in human Chk1, Chk2, and Wee1 protein kinase. | 0 |
| 38266782 | 2024 | OTUB1 Targets CHK1 for Deubiquitination and Stabilization to Facilitate Lung Cancer Progression and Radioresistance. | 0 |
| 38578830 | 2024 | Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates. | 0 |
| 38588804 | 2024 | The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction. | 0 |
| 35231158 | 2023 | When more is less: heritable gain-of-function chk1 mutations impair human fertility. | 4 |
| 36671510 | 2023 | Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses. | 1 |
| 36919124 | 2023 | The Prevalence of CHEK1 and CHEK2 Mutations in Prostate Cancer: a Retrospective Cohort Study. | 1 |
| 37393021 | 2023 | Combined Aurora Kinase A and CHK1 Inhibition Enhances Radiosensitivity of Triple-Negative Breast Cancer Through Induction of Apoptosis and Mitotic Catastrophe Associated With Excessive DNA Damage. | 1 |
| 37715382 | 2023 | Bioinformatic analysis of CHEK1 as a marker of glomerular epithelial cell injury in diabetic nephropathy. | 0 |
| 37762228 | 2023 | Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis. | 1 |
| 37773176 | 2023 | Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1. | 0 |
Citation
Dessen P
CHEK1 (checkpoint kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/210/chek1
