MAX (MYC associated factor X)

2003-02-01  

Identity

HGNC
MAX
LOCATION
14q23.3
LOCUSID
4149
ALIAS
bHLHd4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4149
MIM: 154950
HGNC: 6913
Ensembl: ENSG00000125952

Variants:

dbSNP: 4149
ClinVar: 4149
TCGA: ENSG00000125952
COSMIC: MAX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125952ENST00000246163P61244
ENSG00000125952ENST00000284165P61244
ENSG00000125952ENST00000341653P61244
ENSG00000125952ENST00000358402P61244
ENSG00000125952ENST00000358664P61244
ENSG00000125952ENST00000394606P61244
ENSG00000125952ENST00000394606A0A024R682
ENSG00000125952ENST00000553928P61244
ENSG00000125952ENST00000553928A0A024R682
ENSG00000125952ENST00000555419G3V5L1
ENSG00000125952ENST00000555667Q6V3B1
ENSG00000125952ENST00000555932G3V2N4
ENSG00000125952ENST00000556443G3V2R5
ENSG00000125952ENST00000556892G3V570
ENSG00000125952ENST00000556979P61244
ENSG00000125952ENST00000556979A0A024R682
ENSG00000125952ENST00000557277G3V302
ENSG00000125952ENST00000557746G3V563
ENSG00000125952ENST00000618858P61244
ENSG00000125952ENST00000618858A0A024R682
ENSG00000125952ENST00000651648A0A494C130

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Small cell lung cancerKEGGko05222
MAPK signaling pathwayKEGGhsa04010
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380374902024NMR-identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc-associated factor X.1
381416072024A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.1
380374902024NMR-identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc-associated factor X.1
381416072024A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.1
368023052023MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration.3
371043682023Validation of Myc-Associated Protein X (MAX) regulation in growth hormone secreting and nonfunctional pituitary adenoma.1
368023052023MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration.3
371043682023Validation of Myc-Associated Protein X (MAX) regulation in growth hormone secreting and nonfunctional pituitary adenoma.1
351465592022MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion.5
359389162022Succinate dehydrogenase and MYC-associated factor X mutations in pituitary neuroendocrine tumours.2
360613552022miR-22 Suppresses EMT by Mediating Metabolic Reprogramming in Colorectal Cancer through Targeting MYC-Associated Factor X.3
364848392022Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease.1
351465592022MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion.5
359389162022Succinate dehydrogenase and MYC-associated factor X mutations in pituitary neuroendocrine tumours.2
360613552022miR-22 Suppresses EMT by Mediating Metabolic Reprogramming in Colorectal Cancer through Targeting MYC-Associated Factor X.3

Citation

Dessen P

MAX (MYC associated factor X)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/215/haematological-explorer/css/favicon/deep-insight-explorer/