Identity
HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
MSP23,NKEF-A,NKEFA,PAG,PAGA,PAGB,PRX1,PRXI,TDPX2
FUSION GENES
DNA/RNA
Description
6 exons, 13 kb
Transcription
937 bp mRNA; 599 bp coding sequence
Pseudogene
pseudogene in 9p22
Proteins
Description
199 amino acids; 22 kDa; form dimers through a disulfide bridge
Expression
widely expressed, in particular in the various cell types of the central nervous system and in red blood cells; overexpressed following induction of proliferation and oxidative stress
Localisation
cytosolic
Function
antioxidant, against oxidative stress; Abl SH3-binding protein; inhibitor of c-Abl tyrosine kinase activity; also binds to heme
Homology
thioperoxiredoxines
Implicated in
Disease
Correlations between the expression level and the stage of tumor progrssion in squamous cell carcinoma of the oral cavity; high expression in follicular thyroid tumors, but not in papillary carcinoma of the thyroid
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10535922 | 1999 | Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product. | Hirotsu S et al |
| 9497358 | 1998 | Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. | Kang SW et al |
| 10729633 | 2000 | Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system. | Mizusawa H et al |
| 9506838 | 1998 | The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress. | Prospéri MT et al |
| 10494109 | 1999 | Differential expression of peroxiredoxin subtypes in human brain cell types. | Sarafian TA et al |
| 8691079 | 1996 | Recombinant natural killer enhancing factor augments natural killer cytotoxicity. | Sauri H et al |
| 7702627 | 1995 | Antioxidant function of recombinant human natural killer enhancing factor. | Sauri H et al |
| 8026862 | 1994 | Cloning and sequence analysis of candidate human natural killer-enhancing factor genes. | Shau H et al |
| 8123050 | 1994 | Identification of natural killer enhancing factor as a major antioxidant in human red blood cells. | Shau H et al |
| 9334312 | 1997 | The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. | Wen ST et al |
| 10840156 | 2000 | Peroxiredoxin I expression in oral cancer: a potential new tumor marker. | Yanagawa T et al |
Other Information
Locus ID:
NCBI: 5052
MIM: 176763
HGNC: 9352
Ensembl: ENSG00000117450
Variants:
dbSNP: 5052
ClinVar: 5052
TCGA: ENSG00000117450
COSMIC: PRDX1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37955780 | 2024 | LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation. | 3 |
| 37955780 | 2024 | LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation. | 3 |
| 32881473 | 2023 | PRDX1 stimulates non-small-cell lung carcinoma to proliferate via the Wnt/β-Catenin signaling. | 10 |
| 36587441 | 2023 | Upregulation of exofacial peroxiredoxin-thioredoxin system of lymphocytes and monocytes in preeclampsia. | 0 |
| 37164261 | 2023 | Peroxiredoxin 1 aggravates acute kidney injury by promoting inflammation through Mincle/Syk/NF-κB signaling. | 4 |
| 37259925 | 2023 | A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability. | 4 |
| 37468052 | 2023 | The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway. | 1 |
| 32881473 | 2023 | PRDX1 stimulates non-small-cell lung carcinoma to proliferate via the Wnt/β-Catenin signaling. | 10 |
| 36587441 | 2023 | Upregulation of exofacial peroxiredoxin-thioredoxin system of lymphocytes and monocytes in preeclampsia. | 0 |
| 37164261 | 2023 | Peroxiredoxin 1 aggravates acute kidney injury by promoting inflammation through Mincle/Syk/NF-κB signaling. | 4 |
| 37259925 | 2023 | A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability. | 4 |
| 37468052 | 2023 | The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway. | 1 |
| 34409853 | 2022 | Membrane Bound Peroxiredoxin-1 Serves as a Biomarker for In Vivo Detection of Sessile Serrated Adenomas. | 3 |
| 35460420 | 2022 | The role of human umbilical cord mesenchymal stem cells-derived exosomal microRNA-431-5p in survival and prognosis of colorectal cancer patients. | 9 |
| 34409853 | 2022 | Membrane Bound Peroxiredoxin-1 Serves as a Biomarker for In Vivo Detection of Sessile Serrated Adenomas. | 3 |
Citation
Jean-Loup Huret
PRDX1 (peroxiredoxin 1)
Atlas Genet Cytogenet Oncol Haematol. 2000-12-01
Online version: http://atlasgeneticsoncology.org/gene/266/prdx1
Historical Card
2000-10-01 PRDX1 (peroxiredoxin 1) by Maité P Prosperi,Didier Ferbus,Gérard.Goubin Affiliation
Laboratoire dOncogenese, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France.
