TRG (T cell Receptor Gamma)

2000-07-01   Marie-Paule Lefranc  

IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

Identity

HGNC
TRG
LOCATION
7p14
IMAGE
Atlas Image
LEGEND
for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
LOCUSID
6965
ALIAS
TCRG,TRG@
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image
TRG
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark

Description

  • The human TRG locus at 7p15-p14 spans 160 kb. It consists of 12-15 TRGV genes belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, three TRGJ and the TRGC1 gene, and for the second part, two TRGJ and the TRGC2 gene.
  • The most 5 TRGV genes occupy the most centromeric position, whereas the TRGC2 gene, 3 of the locus, is the most telomeric in the TRG locus.
  • The potentiel repertoire consists of 4-6 functional TRGV genes belonging to two subgroups, the 5 TRGJ and the 2 TRGC genes.
  • Polymorphisms in the number of TRGV genes and in the exon number of the TRGC2 gene have been described in different populations.
  • Enhancer and silencer sequences have been characterized downstream of the TRGC2 gene
  • List of the human TRG genes

    • Mutations

    Note

    Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity name
    Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints

    Other Information

    Locus ID:

    NCBI: 6965
    HGNC: 12271

    Variants:

    dbSNP: 6965
    ClinVar: 6965
    COSMIC: TRG

    References

    Pubmed IDYearTitleCitations
    343650172021Memory and naïve gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy.5
    343650172021Memory and naïve gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy.5
    307645442019Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires.22
    307645442019Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires.22
    282858142017Thymic Determinants of γδ T Cell Differentiation.65
    283683472017The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury.16
    282858142017Thymic Determinants of γδ T Cell Differentiation.65
    283683472017The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury.16
    270780212016Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study (WIHS): A Cross Sectional Study.24
    272107462016RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.59
    273739692016Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications.15
    274129302016[Homology modeling and eukaryotic expression of a modified αβ TCR harboring the immunoglobulin-like domain of γδ TCR].0
    270780212016Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study (WIHS): A Cross Sectional Study.24
    272107462016RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.59
    273739692016Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications.15

    Citation

    Marie-Paule Lefranc

    TRG (T cell Receptor Gamma)

    Atlas Genet Cytogenet Oncol Haematol. 2000-07-01

    Online version: http://atlasgeneticsoncology.org/gene/268