TRG (T cell Receptor Gamma)

2000-07-01   Marie-Paule Lefranc 

IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France


Atlas Image
for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark


Atlas Image
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark


  • The human TRG locus at 7p15-p14 spans 160 kb. It consists of 12-15 TRGV genes belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, three TRGJ and the TRGC1 gene, and for the second part, two TRGJ and the TRGC2 gene.
  • The most 5 TRGV genes occupy the most centromeric position, whereas the TRGC2 gene, 3 of the locus, is the most telomeric in the TRG locus.
  • The potentiel repertoire consists of 4-6 functional TRGV genes belonging to two subgroups, the 5 TRGJ and the 2 TRGC genes.
  • Polymorphisms in the number of TRGV genes and in the exon number of the TRGC2 gene have been described in different populations.
  • Enhancer and silencer sequences have been characterized downstream of the TRGC2 gene
  • List of the human TRG genes
  • Mutations


    Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity name
    Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints

    Other Information

    Locus ID:

    NCBI: 6965
    HGNC: 12271


    dbSNP: 6965
    ClinVar: 6965


    Pubmed IDYearTitleCitations
    219825962011Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.268
    240766362013CD1d-lipid antigen recognition by the γδ TCR.97
    238782182013Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease.46
    198439472009Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis.44
    220459852011Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.42
    221804422012Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).36
    272107462016RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.33
    258649152015The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.27
    282858142017Thymic Determinants of γδ T Cell Differentiation.26
    186243052008Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells.25


    Marie-Paule Lefranc

    TRG (T cell Receptor Gamma)

    Atlas Genet Cytogenet Oncol Haematol. 2000-07-01

    Online version: