RAP2A (RAP2A, member of RAS oncogene family)

2001-05-01   Jean de Gunzburg  

Laboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France

Identity

HGNC
RAP2A
LOCATION
13q32.1
LOCUSID
5911
ALIAS
K-REV,KREV,RAP2,RbBP-30
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image

Description

The gene contains 2 coding exons separated by a large (29,418 bp) intron covering a total of 30,065 bp on chromosome 13

Proteins

Expression

ubiquitous ; higher in brain and hemopoIetic tissues

Localisation

plasma and/or intracellular membranes (endoplasmic reticulum)

Function

unknonw

Homology

90% identical to Rap2B, 60% identical to Rap1, 50 % to Ras proteins

Mutations

Germinal

unknown

Implicated in

Entity name
no implication in pathologies characterized so far

Article Bibliography

Pubmed IDLast YearTitleAuthors
19235071991Post-translational processing and subcellular localization of the Ras-related Rap2 protein.Béranger F et al
95237001998Identification of a specific effector of the small GTP-binding protein Rap2.Janoueix-Lerosey I et al
19002901991The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis.Lerosey I et al
109131892000Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.Ohba Y et al
30457291988Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.Pizon V et al

Other Information

Locus ID:

NCBI: 5911
MIM: 179540
HGNC: 9861
Ensembl: ENSG00000125249

Variants:

dbSNP: 5911
ClinVar: 5911
TCGA: ENSG00000125249
COSMIC: RAP2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125249ENST00000245304P10114
ENSG00000125249ENST00000476869F6U784

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385748912024Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation.0
385748912024Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation.0
350548182022Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.1
352939632022Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration.8
355380312022TGF-β1-induced RAP2 regulates invasion in pancreatic cancer.3
350548182022Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.1
352939632022Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration.8
355380312022TGF-β1-induced RAP2 regulates invasion in pancreatic cancer.3
333139442021lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis.6
340180902021RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.2
340903232021Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.6
333139442021lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis.6
340180902021RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.2
340903232021Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.6
330157962020Abnormal expression of Rap2A as a prognostic marker for human breast cancer.0

Citation

Jean de Gunzburg

RAP2A (RAP2A, member of RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2001-05-01

Online version: http://atlasgeneticsoncology.org/gene/274