TRD (T cell Receptor Delta)

2000-07-01   Marie-Paule Lefranc 

IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

Identity

HGNC
LOCATION
14q11.2
IMAGE
Atlas Image
LEGEND
for complete Figure, see: chromosome 14, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
LOCUSID
ALIAS
TCRD,TCRDV1,TRD@

DNA/RNA

Atlas Image
TRA/TRD
V-GENE: Green box: Functional; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: Pseudogene.
C-GENE: Blue: Functional.
for complete Figure, see: locus TRD IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark

Description

  • The human TRD locus at 14q11.2 comprises a cluster of one TRDV gene (TRDV2), three TRDD segments, and four TRDJ segments, upstream of the unique TRDC gene; another TRDV gene (TRDV3) is localized downstream of the TRDC gene, in inverted orientation of transcription.
  • This cluster spans 60 kb and is localized inside the TRA locus, between the TRAV genes and the TRAJ segments. One TRDV gene (TRDV1) is localized at 360 kb upstream of the TRDC gene, among the TRAV genes. Five variable genes have been found rearranged to both (D)J segments of the TRD locus and TRAJ segments, and can therefore be used for the synthesis of both delta and alpha chains. These genes are described as TRAV/DV.
  • The TRDV genes are unique members of different subgroups. All the TRD genes are functional, with the exception of one TRAV/DV, which has been found either functional or as a pseudogene.
  • Enhancer sequences have been described between the TRDJ3 and the TRDC gene.
  • List of the human TRD genes
  • Mutations

    Note

    Mutations which correspond to allelic polymorphisms of the functional germline TRDV, TRDD, TRDJ and TRDC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity name
    Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRDV, TRDD or TRDJ recombination signals or isolated heptamer are frequently observed at the breakpoints.
    Prognosis
    median survival > 5 yrs in children
    Entity name
    t(8;14)(q24;q11); involve TRD - MYC in 8q24
    Disease
    T-cell acute lymphocytic leukemia (ALL); rare
    Entity name
    t(10;14)(q24;q11); involve TRD - HOX11 in 10q24
    Disease
    T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
    Prognosis
    not unfavourable
    Entity name
    t(11;14)(p13;q11); involve TRD - RBTN2 in 11p13
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(11;14)(p15;q11); involve TRD - RBTN1 in 11p15
    Disease
    T-cell Acute lymphocytic leukemia (ALL)
    Entity name
    Disease
    T-cell prolymphocytic leukemia (T-PLL) and adult T cell leukemia/lymphoma
    Prognosis
    poor

    Breakpoints

    Atlas Image

    Other Information

    Locus ID:

    NCBI: 6964
    HGNC: 12252

    Variants:

    dbSNP: 6964
    ClinVar: 6964
    COSMIC: TRD

    References

    Pubmed IDYearTitleCitations
    219825962011Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.268
    240766362013CD1d-lipid antigen recognition by the γδ TCR.97
    147347452004Ontogeny of gamma delta T cells in humans.59
    238782182013Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease.46
    198439472009Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis.44
    220459852011Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.42
    221804422012Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).36
    272107462016RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.33
    183218592008Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy.27
    258649152015The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.27

    Citation

    Marie-Paule Lefranc

    TRD (T cell Receptor Delta)

    Atlas Genet Cytogenet Oncol Haematol. 2000-07-01

    Online version: http://atlasgeneticsoncology.org/gene/279/tcrdid279