ERCC3 (Excision repair cross-complementing rodent repair deficiency, complementation group 3)

2001-02-01   Anne Stary  , Alain Sarasin  

Laboratory of Genetic Instability, Cancer, UPR2169 CNRS, Institut de Recherches sur le Cancer, 7, rue guy Moquet, BP 8, 94801 VILLEJUIF, France

Identity

HGNC
ERCC3
LOCATION
2q14.3
IMAGE
Atlas Image
LEGEND
XPB (2q21) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
2071
ALIAS
BTF2,GTF2H,RAD25,Ssl2,TFIIH,TTD2,XPB
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

2751 b mRNA

Proteins

Expression

ubiquitous

Localisation

nuclear

Function

DNA excision repair protein. 3-5 ATP-dependent helicase activity involved in excision DNA repair and initiation of basal transcription
  • The XPB protein displays a 3-5 helicase activity. This protein is a subunit of the basal transcription factor TFIIH involved in both Nucleotide Excision Repair (NER) and the initiation of RNA polymerase II . Indeed, TFIIH fulfills a dual role in transcription initiation and NER and the role of TFIIH in NER might closely mimic its role in the transcription initiation process. In transcription initiation TFIIH is thought to be involved in unwinding of the promoter site to allowing promoter clearance. In the NER process TFIIH causes unwinding of the lesion-containing region that has been localized by XPC-HR23B and XPA-RPA, enabling the accumulation of NER proteins around the damaged site.
  • Among the Xeroderma pigmentosum (XP) patients, XPB patients are extremely rare (only 3 patients known in the world) due to the fact that the XPB gene product is essential for transcription initiation and in all cases, these patients show the double symptoms of Xeroderma pigmentosum and Cockayne syndrome (CS) (see below).

    • Homology

    haywire gene (FLYBASE, hay) ; Ercc3 (MGI : 95414)

    Mutations

    Germinal

    F99S (T296C) is found in two XPB/CS patients; T119P (A355C) is found in two TTD/XPB patients; FS740 is found in one XPB/CS patient

    Implicated in

    Entity name
    ERCC3/XPB
    Disease
    Xeroderma pigmentosum and Cockayne syndrome in the same patient or Trichothiodystrophy. Early skin cancers

    Bibliography

    Pubmed IDLast YearTitleAuthors

    Other Information

    Locus ID:

    NCBI: 2071
    MIM: 133510
    HGNC: 3435
    Ensembl: ENSG00000163161

    Variants:

    dbSNP: 2071
    ClinVar: 2071
    TCGA: ENSG00000163161
    COSMIC: ERCC3

    RNA/Proteins

    Gene IDTranscript IDUniprot
    ENSG00000163161ENST00000285398P19447
    ENSG00000163161ENST00000426778F2Z2V4
    ENSG00000163161ENST00000445889F2Z2V4
    ENSG00000163161ENST00000456257H7C309
    ENSG00000163161ENST00000642308A0A2R8YFS3
    ENSG00000163161ENST00000644317A0A2R8Y4R8
    ENSG00000163161ENST00000645233A0A2R8YFS3
    ENSG00000163161ENST00000645467A0A2R8Y5L2
    ENSG00000163161ENST00000645504A0A2R8Y681
    ENSG00000163161ENST00000645736A0A2R8YES7
    ENSG00000163161ENST00000646654A0A2R8Y5H0
    ENSG00000163161ENST00000647169A0A2R8Y6W8
    ENSG00000163161ENST00000647496A0A2R8Y762

    Expression (GTEx)

    0
    10
    20
    30
    40
    50
    60
    70
    80
    90
    100
    Adipose - Subcutaneous
    Adipose - Visceral
    Adrenal Gland
    Artery - Aorta
    Artery - Tibial
    Bladder
    Brain - Amygdala
    Brain - Anterior cingulate cortex
    Brain - Caudate
    Brain - Cerebellar Hemisphere
    Brain - Cerebellum
    Brain - Cortex
    Brain - Frontal Cortex
    Brain - Hippocampus
    Brain - Hypothalamus
    Brain - Nucleus accumbens
    Brain - Putamen
    Brain - Spinal cord
    Brain - Substantia nigra
    Breast - Mammary Tissue
    Cells - Cultured fibroblasts
    Cells - EBV - transformed lymphocytes
    Cervix - Ectocervix
    Cervix - Endocervix
    Colon - Sigmoid
    Colon - Transverse
    Esophagus - Gastroesophageal Junction
    Esophagus - Mucosa
    Esophagus - Muscularis
    Fallopian Tube
    Heart - Atrial Appendage
    Heart - Left Ventricle
    Kidney - Cortex
    Kidney - Medulla
    Liver
    Lung
    Minor Salivary Gland
    Muscle - Skeletal
    Nerve - Tibial
    Ovary
    Pancreas
    Pituitary
    Prostate
    Skin - Not Sun Exposed
    Skin - Sun Exposed
    Small Intestine - Terminal Ileum
    Spleen
    Stomach
    Testis
    Thyroid
    Uterus
    Vagina
    Whole Blood

    Pathways

    PathwaySourceExternal ID
    Basal transcription factorsKEGGko03022
    Nucleotide excision repairKEGGko03420
    Basal transcription factorsKEGGhsa03022
    Nucleotide excision repairKEGGhsa03420
    Holo-TFIIH complexKEGGhsa_M00290
    Holo-TFIIH complexKEGGM00290
    DiseaseREACTOMER-HSA-1643685
    Infectious diseaseREACTOMER-HSA-5663205
    HIV InfectionREACTOMER-HSA-162906
    HIV Life CycleREACTOMER-HSA-162587
    Late Phase of HIV Life CycleREACTOMER-HSA-162599
    Transcription of the HIV genomeREACTOMER-HSA-167172
    HIV Transcription InitiationREACTOMER-HSA-167161
    RNA Polymerase II HIV Promoter EscapeREACTOMER-HSA-167162
    RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionREACTOMER-HSA-167160
    HIV Transcription ElongationREACTOMER-HSA-167169
    Formation of the HIV-1 Early Elongation ComplexREACTOMER-HSA-167158
    Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
    Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
    Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
    Gene ExpressionREACTOMER-HSA-74160
    Generic Transcription PathwayREACTOMER-HSA-212436
    Transcriptional Regulation by TP53REACTOMER-HSA-3700989
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
    RNA Polymerase I TranscriptionREACTOMER-HSA-73864
    RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
    RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
    RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772
    RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
    RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
    RNA Polymerase II TranscriptionREACTOMER-HSA-73857
    RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
    RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningREACTOMER-HSA-73779
    RNA Polymerase II Transcription Initiation And Promoter ClearanceREACTOMER-HSA-76042
    RNA Polymerase II Transcription InitiationREACTOMER-HSA-75953
    RNA Polymerase II Promoter EscapeREACTOMER-HSA-73776
    RNA Pol II CTD phosphorylation and interaction with CEREACTOMER-HSA-77075
    RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
    Formation of the Early Elongation ComplexREACTOMER-HSA-113418
    Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
    mRNA CappingREACTOMER-HSA-72086
    Epigenetic regulation of gene expressionREACTOMER-HSA-212165
    Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
    NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
    DNA RepairREACTOMER-HSA-73894
    Nucleotide Excision RepairREACTOMER-HSA-5696398
    Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
    Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
    Dual Incision in GG-NERREACTOMER-HSA-5696400
    Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
    Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
    Dual incision in TC-NERREACTOMER-HSA-6782135
    Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210
    TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648

    Protein levels (Protein atlas)

    Not detected
    Low
    Medium
    High
    cerebral cortex
    cerebellum
    hippocampus
    caudate
    thyroid gland
    parathyroid gland
    adrenal gland
    bronchus
    lung
    oral mucosa
    salivary gland
    esophagus
    stomach 1
    stomach 2
    duodenum
    small intestine
    colon
    rectum
    liver
    gallbladder
    pancreas
    kidney
    urinary bladder
    testis
    epididymis
    seminal vesicle
    prostate
    vagina
    ovary
    fallopian tube
    endometrium 1
    endometrium 2
    cervix, uterine
    placenta
    breast
    heart muscle
    smooth muscle
    skeletal muscle
    soft tissue 1
    soft tissue 2
    adipose tissue
    skin 1
    skin 2
    appendix
    spleen
    lymph node
    tonsil
    bone marrow

    PharmGKB

    Entity IDNameTypeEvidenceAssociationPKPDPMIDs
    PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD25069034
    PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD25069034

    References

    Pubmed IDYearTitleCitations
    364727492023Comprehensive analysis of ERCC3 prognosis value and ceRNA network in AML.1
    364727492023Comprehensive analysis of ERCC3 prognosis value and ceRNA network in AML.1
    359477452022Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB.14
    359477452022Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB.14
    333819972021Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97.5
    333819972021Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97.5
    318328832020Associations between expression levels of nine core nucleotide excision repair genes in lymphocytes and risk of head and neck squamous cell carcinomas in a Chinese population.5
    321517982020Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3.7
    322682702020MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma.1
    324349202020Epstein-Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters.7
    325575692020Early-onset nucleotide excision repair disorders with neurological impairment: Clues for early diagnosis and prognostic counseling.5
    331259432020ERCC3, a new ovarian cancer susceptibility gene?4
    318328832020Associations between expression levels of nine core nucleotide excision repair genes in lymphocytes and risk of head and neck squamous cell carcinomas in a Chinese population.5
    321517982020Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3.7
    322682702020MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma.1

    Citation

    Anne Stary ; Alain Sarasin

    ERCC3 (Excision repair cross-complementing rodent repair deficiency, complementation group 3)

    Atlas Genet Cytogenet Oncol Haematol. 2001-02-01

    Online version: http://atlasgeneticsoncology.org/gene/296/favicon/js/js/lib/all.min.js