Centre Jean-Perrin, BP 392, 63000 Clermont-Ferrand, France
Chk2 is also involved in the regulation of BRCA1. Under normal conditions the two proteins are associated; after irradiation Chk2 phosphorylates Ser988 of BRCA1. This step is required for their dissociation, and the liberated BRCA1 participates directly in DNA repair and cell cycle arrest.
Finally, Chk2 can provoke apoptosis independently of p53, for example via phosphorylation of PML.
CHEK2 (CHK2 checkpoint homolog (S. pombe))
Atlas Genet Cytogenet Oncol Haematol. 2004-05-01
Online version: http://atlasgeneticsoncology.org/gene/312/chek2id312