RELB (v-rel reticuloendotheliosis viral oncogene homolog B)

2002-01-01   Fei Chen  

Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

Identity

HGNC
RELB
LOCATION
19q13.32
LOCUSID
5971
ALIAS
I-REL,IMD53,IREL,REL-B
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

The gene encoding human RelB has 11 exons spanning ~ 37 kb. Analysis of the 5-flanking region of human relb gene indicates that RelB transcription is dependent on a TATA-less promoter containing two kB sites. Thus, while relA is constitutively expressed, the expression of both rel and relb is in an inducible fashion and dependent on NF-kB.

Proteins

Expression

wide.

Localisation

cytosol, nuclei after activation.

Function

regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family.

Implicated in

Entity name
cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.

Article Bibliography

Pubmed IDLast YearTitleAuthors
87175281996The NF-kappa B and I kappa B proteins: new discoveries and insights.Baldwin AS Jr et al
81835651994Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.Bours V et al
95971301998NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.Ghosh S et al
15772701992I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.Ruben SM et al

Other Information

Locus ID:

NCBI: 5971
MIM: 604758
HGNC: 9956
Ensembl: ENSG00000104856

Variants:

dbSNP: 5971
ClinVar: 5971
TCGA: ENSG00000104856
COSMIC: RELB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104856ENST00000221452Q01201
ENSG00000104856ENST00000505236D6R992
ENSG00000104856ENST00000509480D6RIV7
ENSG00000104856ENST00000589972K7ERX9
ENSG00000104856ENST00000625761Q01201

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signalingREACTOMER-HSA-5607761
CD209 (DC-SIGN) signalingREACTOMER-HSA-5621575
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
NIK-->noncanonical NF-kB signalingREACTOMER-HSA-5676590

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33678PPP3CAGenePathwayassociated23922006
PA33679PPP3CBGenePathwayassociated23922006
PA33680PPP3CCGenePathwayassociated23922006
PA33681PPP3R1GenePathwayassociated23922006
PA33682PPP3R2GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
364026022023NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity.4
368634512023RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm.0
371755302023NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells.1
381393782023Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4.1
364026022023NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity.4
368634512023RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm.0
371755302023NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells.1
381393782023Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4.1
342329792022The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma.20
349330922022RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro.7
361108482022RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.2
342329792022The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma.20
349330922022RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro.7
361108482022RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.2
340474632021Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression.2

Citation

Fei Chen

RELB (v-rel reticuloendotheliosis viral oncogene homolog B)

Atlas Genet Cytogenet Oncol Haematol. 2002-01-01

Online version: http://atlasgeneticsoncology.org/gene/324/favicon/case-report-explorer/haematological-explorer/