RELB (v-rel reticuloendotheliosis viral oncogene homolog B)

2002-01-01 Fei Chen Affiliation

Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

Identity

HGNC

RELB

LOCATION

19q13.32

LOCUSID

5971

ALIAS

I-REL,IMD53,IREL,REL-B

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

The gene encoding human RelB has 11 exons spanning ~ 37 kb. Analysis of the 5-flanking region of human relb gene indicates that RelB transcription is dependent on a TATA-less promoter containing two kB sites. Thus, while relA is constitutively expressed, the expression of both rel and relb is in an inducible fashion and dependent on NF-kB.

Proteins

Expression

wide.

Localisation

cytosol, nuclei after activation.

Function

regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family.

Implicated in

Entity name

cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.

Bibliography

Pubmed ID	Last Year	Title	Authors
8717528	1996	The NF-kappa B and I kappa B proteins: new discoveries and insights.	Baldwin AS Jr et al
8183565	1994	Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.	Bours V et al
9597130	1998	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	Ghosh S et al
1577270	1992	I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.	Ruben SM et al

Other Information

Locus ID:

NCBI: 5971
MIM: 604758
HGNC: 9956
Ensembl: ENSG00000104856

Variants:

dbSNP: 5971
ClinVar: 5971
TCGA: ENSG00000104856
COSMIC: RELB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104856	ENST00000221452	Q01201
ENSG00000104856	ENST00000505236	D6R992
ENSG00000104856	ENST00000509480	D6RIV7
ENSG00000104856	ENST00000589972	K7ERX9
ENSG00000104856	ENST00000625761	Q01201

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
MAPK signaling pathway	KEGG	hsa04010
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signaling	REACTOME	R-HSA-5607761
CD209 (DC-SIGN) signaling	REACTOME	R-HSA-5621575
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
NIK-->noncanonical NF-kB signaling	REACTOME	R-HSA-5676590

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA33678	PPP3CA	Gene	Pathway	associated	23922006
PA33679	PPP3CB	Gene	Pathway	associated	23922006
PA33680	PPP3CC	Gene	Pathway	associated	23922006
PA33681	PPP3R1	Gene	Pathway	associated	23922006
PA33682	PPP3R2	Gene	Pathway	associated	23922006

References

Pubmed ID	Year	Title	Citations
36402602	2023	NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity.	4
36863451	2023	RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm.	0
37175530	2023	NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells.	1
38139378	2023	Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4.	1
36402602	2023	NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity.	4
36863451	2023	RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm.	0
37175530	2023	NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells.	1
38139378	2023	Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4.	1
34232979	2022	The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma.	20
34933092	2022	RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro.	7
36110848	2022	RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.	2
34232979	2022	The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma.	20
34933092	2022	RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro.	7
36110848	2022	RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.	2
34047463	2021	Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression.	2

Citation

Fei Chen

RELB (v-rel reticuloendotheliosis viral oncogene homolog B)

Atlas Genet Cytogenet Oncol Haematol. 2002-01-01

Online version: http://atlasgeneticsoncology.org/gene/324/js/cancer-prone-explorer/deep-insight-explorer/