RAD51C (RAD51 paralog C)

2003-02-01 Affiliation

Identity

HGNC

RAD51C

LOCATION

17q22

LOCUSID

5889

ALIAS

BROVCA3,FANCO,R51H3,RAD51L2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5889
MIM: 602774
HGNC: 9820
Ensembl: ENSG00000108384

Variants:

dbSNP: 5889
ClinVar: 5889
TCGA: ENSG00000108384
COSMIC: RAD51C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108384	ENST00000337432	O43502
ENSG00000108384	ENST00000413590	H7C1R0
ENSG00000108384	ENST00000421782	O43502
ENSG00000108384	ENST00000425173	H7C2Q5
ENSG00000108384	ENST00000461271	J3QR58
ENSG00000108384	ENST00000475762	E9PI66
ENSG00000108384	ENST00000482007	Q7KZJ0
ENSG00000108384	ENST00000486827	E9PI66
ENSG00000108384	ENST00000487525	Q7KZJ0
ENSG00000108384	ENST00000583539	J3QKK3
ENSG00000108384	ENST00000584617	J3QLB5
ENSG00000108384	ENST00000584804	J3QLQ2
ENSG00000108384	ENST00000622327	A0A087WZ35

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Homologous recombination	KEGG	ko03440
Homologous recombination	KEGG	hsa03440
Fanconi anemia pathway	KEGG	ko03460
Fanconi anemia pathway	KEGG	hsa03460
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Cell Cycle	REACTOME	R-HSA-1640170
Meiosis	REACTOME	R-HSA-1500620
Meiotic recombination	REACTOME	R-HSA-912446
DNA Repair	REACTOME	R-HSA-73894
DNA Double-Strand Break Repair	REACTOME	R-HSA-5693532
Homology Directed Repair	REACTOME	R-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	REACTOME	R-HSA-5693567
HDR through Homologous Recombination (HRR)	REACTOME	R-HSA-5685942
Homologous DNA Pairing and Strand Exchange	REACTOME	R-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchange	REACTOME	R-HSA-5693616
Resolution of D-Loop Structures	REACTOME	R-HSA-5693537
Resolution of D-loop Structures through Holliday Junction Intermediates	REACTOME	R-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	REACTOME	R-HSA-5693554

References

Pubmed ID	Year	Title	Citations
38330859	2024	Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site.	0
38330859	2024	Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site.	0
36411032	2023	UK consensus recommendations for clinical management of cancer risk for women with germline pathogenic variants in cancer predisposition genes: RAD51C, RAD51D, BRIP1 and PALB2.	7
36562461	2023	Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection.	2
37031326	2023	SNV/indel hypermutator phenotype in biallelic RAD51C variant: Fanconi anemia.	0
37253112	2023	Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C.	1
37344587	2023	Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.	10
37344589	2023	Structural insights into BCDX2 complex function in homologous recombination.	7
37488098	2023	RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.	6
36411032	2023	UK consensus recommendations for clinical management of cancer risk for women with germline pathogenic variants in cancer predisposition genes: RAD51C, RAD51D, BRIP1 and PALB2.	7
36562461	2023	Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection.	2
37031326	2023	SNV/indel hypermutator phenotype in biallelic RAD51C variant: Fanconi anemia.	0
37253112	2023	Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C.	1
37344587	2023	Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.	10
37344589	2023	Structural insights into BCDX2 complex function in homologous recombination.	7

Citation

Dessen P

RAD51C (RAD51 paralog C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/346