Internally truncated transcripts described in different cancers (Ishii et al., 1999): - Frameshift deletion 1546-1542 (exons affected: 1,2,3) reported in esophagus cancer - In-frame deletion 558-1715 (exons affected: 2,3) reported in esophagus cancer - In-frame deletion 1366-1641 (exon affected: 3) reported in prostate cancer - In-frame deletion 1402-1578 (exon affected: 3) reported in esophagus and prostate cancer and in acute lymphoblastic leukemia - In-frame deletion 1417-1515 (exon affected: 3) reported in melanoma - In-frame deletion 1516-1584 (exon affected: 3) reported in melanoma.
A detailed DNA sequence analysis of LZTS1 gene performed in germline DNA extracted from a screening panel of sporadic and hereditary prostate cancers revealed the presence of 24 SNP. The four SNP listed below have a statistically significant association with sporadic prostate cancer (Hawkins et al., 2002): - A allele of WF101-010 (2812G → A) - C allele of WF101-012 (2883T → C) - C allele of WF101-031 (3329C → T) - G allele of WF101-014 (4361C → T).
NCBI: 11178 MIM: 606551 HGNC: 13861 Ensembl: ENSG00000061337
dbSNP: 11178 ClinVar: 11178 TCGA: ENSG00000061337 COSMIC: LZTS1
Andrea Vecchione ; Luca Lavra ; Carlo M Croce
LZTS1 (leucine zipper, putative tumor suppressor 1)
Atlas Genet Cytogenet Oncol Haematol. 2012-06-01
Online version: http://atlasgeneticsoncology.org/gene/367/js/css/lib/js/_common.js