CDK13 (cyclin dependent kinase 13)

2003-11-01  

Identity

HGNC
CDK13
LOCATION
7p14.1
LOCUSID
8621
ALIAS
CDC2L,CDC2L5,CHDFIDD,CHED,hCDK13
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8621
MIM: 603309
HGNC: 1733
Ensembl: ENSG00000065883

Variants:

dbSNP: 8621
ClinVar: 8621
TCGA: ENSG00000065883
COSMIC: CDK13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065883ENST00000181839Q14004
ENSG00000065883ENST00000181839A0A024RA85
ENSG00000065883ENST00000340829Q14004
ENSG00000065883ENST00000340829A0A024RA66
ENSG00000065883ENST00000484589A0A2R8YD28
ENSG00000065883ENST00000611390A0A087X209
ENSG00000065883ENST00000613626Q9BVE2
ENSG00000065883ENST00000642592A0A2R8YEB7
ENSG00000065883ENST00000642626A0A2R8YCQ1
ENSG00000065883ENST00000643859A0A2R8Y7W5
ENSG00000065883ENST00000643868A0A2R8YFE7
ENSG00000065883ENST00000643915A0A2R8YF61
ENSG00000065883ENST00000645470A0A2R8Y644
ENSG00000065883ENST00000646039A0A2R8Y4Z0
ENSG00000065883ENST00000646437A0A2R8Y7Y0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365999382023CDK13-related disorder: a deep characterization of speech and language abilities and addition of 33 novel cases.2
370264852023CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1.8
370796852023Oncogenic CDK13 mutations impede nuclear RNA surveillance.4
378453852023CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA.4
365999382023CDK13-related disorder: a deep characterization of speech and language abilities and addition of 33 novel cases.2
370264852023CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1.8
370796852023Oncogenic CDK13 mutations impede nuclear RNA surveillance.4
378453852023CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA.4
332920202022Expression of CDK13 Was Associated with Prognosis and Expression of HIF-1α and beclin1 in Breast Cancer Patients.2
350633502022CDK13-related disorder: Report of a series of 18 previously unpublished individuals and description of an epigenetic signature.5
332920202022Expression of CDK13 Was Associated with Prognosis and Expression of HIF-1α and beclin1 in Breast Cancer Patients.2
350633502022CDK13-related disorder: Report of a series of 18 previously unpublished individuals and description of an epigenetic signature.5
333901862021CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis.24
338798372021Wolfram-like syndrome with bicuspid aortic valve due to a homozygous missense variant in CDK13.2
343800302021HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.9

Citation

Dessen P

CDK13 (cyclin dependent kinase 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40009