CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme)

2003-02-01 Affiliation

Identity

HGNC

CDC34

LOCATION

19p13.3

LOCUSID

997

ALIAS

E2-CDC34,UBC3,UBCH3,UBE2R1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 997
MIM: 116948
HGNC: 1734
Ensembl: ENSG00000099804

Variants:

dbSNP: 997
ClinVar: 997
TCGA: ENSG00000099804
COSMIC: CDC34

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000099804	ENST00000215574	P49427
ENSG00000099804	ENST00000215574	A0A024R1Z1
ENSG00000099804	ENST00000586283	U3KPV8
ENSG00000099804	ENST00000606065	U3KQ77
ENSG00000099804	ENST00000607527	U3KQP9

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Ubiquitin mediated proteolysis	KEGG	hsa04120
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Downstream TCR signaling	REACTOME	R-HSA-202424
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Innate Immune System	REACTOME	R-HSA-168249
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Protein ubiquitination	REACTOME	R-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	REACTOME	R-HSA-8866652

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32114396	2020	Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis.	11
32268269	2020	Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy.	5
32114396	2020	Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis.	11
32268269	2020	Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy.	5
31868589	2019	Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.	28
31868589	2019	Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.	28
29564676	2018	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	2
29564676	2018	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	2
27044868	2016	Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.	11
27044868	2016	Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.	11
25425648	2015	Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.	15
25471371	2015	Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.	17
25425648	2015	Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.	15
25471371	2015	Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.	17
23465077	2013	FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.	35

Citation

Dessen P

CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40010