CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)

2003-05-01 Affiliation

Identity

HGNC

CDK5R1

LOCATION

17q11.2

LOCUSID

8851

ALIAS

CDK5P35,CDK5R,NCK5A,p23,p25,p35,p35nck5a

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8851
MIM: 603460
HGNC: 1775
Ensembl: ENSG00000176749

Variants:

dbSNP: 8851
ClinVar: 8851
TCGA: ENSG00000176749
COSMIC: CDK5R1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000176749	ENST00000313401	Q15078
ENSG00000176749	ENST00000584716	J3QRB5
ENSG00000176749	ENST00000584792	J3QRB5

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Alzheimer's disease	KEGG	ko05010
Alzheimer's disease	KEGG	hsa05010
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Disease	REACTOME	R-HSA-1643685
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
CRMPs in Sema3A signaling	REACTOME	R-HSA-399956
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
Neurodegenerative Diseases	REACTOME	R-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	REACTOME	R-HSA-8862803

References

Pubmed ID	Year	Title	Citations
37899376	2023	Tumor-suppressive microRNA-152 inhibits the proliferation of Ewing's sarcoma cells by targeting CDK5R1.	0
37899376	2023	Tumor-suppressive microRNA-152 inhibits the proliferation of Ewing's sarcoma cells by targeting CDK5R1.	0
33346796	2021	Elevated CDK5R1 predicts worse prognosis in hepatocellular carcinoma based on TCGA data.	6
33346796	2021	Elevated CDK5R1 predicts worse prognosis in hepatocellular carcinoma based on TCGA data.	6
30718749	2019	The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication.	5
30718749	2019	The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication.	5
29997370	2018	Multiple Layers of CDK5R1 Regulation in Alzheimer's Disease Implicate Long Non-Coding RNAs.	44
29997370	2018	Multiple Layers of CDK5R1 Regulation in Alzheimer's Disease Implicate Long Non-Coding RNAs.	44
27343180	2017	The miR-15/107 Family of microRNA Genes Regulates CDK5R1/p35 with Implications for Alzheimer's Disease Pathogenesis.	48
27343180	2017	The miR-15/107 Family of microRNA Genes Regulates CDK5R1/p35 with Implications for Alzheimer's Disease Pathogenesis.	48
26657932	2016	Functional characterization of CDK5 and CDK5R1 mutations identified in patients with non-syndromic intellectual disability.	9
27387995	2016	Computational study of the inhibitory mechanism of the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.	6
26657932	2016	Functional characterization of CDK5 and CDK5R1 mutations identified in patients with non-syndromic intellectual disability.	9
27387995	2016	Computational study of the inhibitory mechanism of the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.	6
25391294	2015	Sumoylation of p35 modulates p35/cyclin-dependent kinase (Cdk) 5 complex activity.	7

Citation

Dessen P

CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40034/img/js/lib/favicon/favicon-32x32.png