CDK7 (cyclin dependent kinase 7)

2003-08-01  

Identity

HGNC
LOCATION
5q13.2
LOCUSID
ALIAS
CAK,CAK1,CDKN7,HCAK,MO15,STK1,p39MO15
FUSION GENES

Other Information

Locus ID:

NCBI: 1022
MIM: 601955
HGNC: 1778
Ensembl: ENSG00000134058

Variants:

dbSNP: 1022
ClinVar: 1022
TCGA: ENSG00000134058
COSMIC: CDK7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134058ENST00000256443P50613
ENSG00000134058ENST00000256443A0A0S2Z3F9
ENSG00000134058ENST00000502604D6R9G1
ENSG00000134058ENST00000504147D6R9Z2
ENSG00000134058ENST00000506563D6REC6
ENSG00000134058ENST00000506789D6RI01
ENSG00000134058ENST00000508726D6RF14
ENSG00000134058ENST00000510106D6RFL0
ENSG00000134058ENST00000514676D6RAD4
ENSG00000134058ENST00000515180D6RGG9
ENSG00000134058ENST00000515391D6RIG9
ENSG00000134058ENST00000626796D6R9Z2
ENSG00000134058ENST00000629350D6RF14

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Basal transcription factorsKEGGko03022
Nucleotide excision repairKEGGko03420
Cell cycleKEGGko04110
Basal transcription factorsKEGGhsa03022
Nucleotide excision repairKEGGhsa03420
Cell cycleKEGGhsa04110
Holo-TFIIH complexKEGGhsa_M00290
Holo-TFIIH complexKEGGM00290
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription InitiationREACTOMER-HSA-167161
RNA Polymerase II HIV Promoter EscapeREACTOMER-HSA-167162
RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionREACTOMER-HSA-167160
HIV Transcription ElongationREACTOMER-HSA-167169
Formation of the HIV-1 Early Elongation ComplexREACTOMER-HSA-167158
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningREACTOMER-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter ClearanceREACTOMER-HSA-76042
RNA Polymerase II Transcription InitiationREACTOMER-HSA-75953
RNA Polymerase II Promoter EscapeREACTOMER-HSA-73776
RNA Pol II CTD phosphorylation and interaction with CEREACTOMER-HSA-77075
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of the Early Elongation ComplexREACTOMER-HSA-113418
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
mRNA CappingREACTOMER-HSA-72086
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375517452024CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.2
386053212024CDK7 in breast cancer: mechanisms of action and therapeutic potential.1
388210492024CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release.0
375517452024CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.2
386053212024CDK7 in breast cancer: mechanisms of action and therapeutic potential.1
388210492024CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release.0
364010942023Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.1
372015852023Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction.3
373859872023Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression.5
375913142023Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.4
364010942023Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.1
372015852023Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction.3
373859872023Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression.5
375913142023Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.4
335032752022Pharmacological inhibition of CDK7 by THZ1 impairs tumor growth in p53-mutated HNSCC.3

Citation

Dessen P

CDK7 (cyclin dependent kinase 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40035/cdk7-(cyclin-dependent-kinase-7)