CDK7 (cyclin dependent kinase 7)

2003-08-01  

Identity

HGNC
LOCATION
5q13.2
LOCUSID
ALIAS
CAK,CAK1,CDKN7,HCAK,MO15,STK1,p39MO15
FUSION GENES

Other Information

Locus ID:

NCBI: 1022
MIM: 601955
HGNC: 1778
Ensembl: ENSG00000134058

Variants:

dbSNP: 1022
ClinVar: 1022
TCGA: ENSG00000134058
COSMIC: CDK7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134058ENST00000256443P50613
ENSG00000134058ENST00000256443A0A0S2Z3F9
ENSG00000134058ENST00000502604D6R9G1
ENSG00000134058ENST00000504147D6R9Z2
ENSG00000134058ENST00000506563D6REC6
ENSG00000134058ENST00000506789D6RI01
ENSG00000134058ENST00000508726D6RF14
ENSG00000134058ENST00000510106D6RFL0
ENSG00000134058ENST00000514676D6RAD4
ENSG00000134058ENST00000515180D6RGG9
ENSG00000134058ENST00000515391D6RIG9
ENSG00000134058ENST00000626796D6R9Z2
ENSG00000134058ENST00000629350D6RF14

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Basal transcription factorsKEGGko03022
Nucleotide excision repairKEGGko03420
Cell cycleKEGGko04110
Basal transcription factorsKEGGhsa03022
Nucleotide excision repairKEGGhsa03420
Cell cycleKEGGhsa04110
Holo-TFIIH complexKEGGhsa_M00290
Holo-TFIIH complexKEGGM00290
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription InitiationREACTOMER-HSA-167161
RNA Polymerase II HIV Promoter EscapeREACTOMER-HSA-167162
RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionREACTOMER-HSA-167160
HIV Transcription ElongationREACTOMER-HSA-167169
Formation of the HIV-1 Early Elongation ComplexREACTOMER-HSA-167158
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningREACTOMER-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter ClearanceREACTOMER-HSA-76042
RNA Polymerase II Transcription InitiationREACTOMER-HSA-75953
RNA Polymerase II Promoter EscapeREACTOMER-HSA-73776
RNA Pol II CTD phosphorylation and interaction with CEREACTOMER-HSA-77075
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of the Early Elongation ComplexREACTOMER-HSA-113418
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
mRNA CappingREACTOMER-HSA-72086
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196670752009TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.135
230646452012Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.130
264063772015CDK7-dependent transcriptional addiction in triple-negative breast cancer.111
173862612007Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.102
262572812015THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing.57
163278052006Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.48
170122222007Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells.46
206220042010Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.40
236225152013A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.35
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32

Citation

Dessen P

CDK7 (cyclin dependent kinase 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40035/cdk7-(cyclin-dependent-kinase-7)