Identity
HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
CDW52,EDDM5,HE5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1043
MIM: 114280
HGNC: 1804
Ensembl: ENSG00000169442
Variants:
dbSNP: 1043
ClinVar: 1043
TCGA: ENSG00000169442
COSMIC: CD52
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169442 | ENST00000374213 | P31358 |
| ENSG00000169442 | ENST00000374213 | V9HWN9 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37975535 | 2024 | CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma. | 0 |
| 37975535 | 2024 | CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma. | 0 |
| 37314354 | 2023 | Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia. | 40 |
| 37314354 | 2023 | Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia. | 40 |
| 33705353 | 2021 | High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes. | 2 |
| 33705353 | 2021 | High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes. | 2 |
| 32875608 | 2020 | Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype complicating alemtuzumab treatment in T-cell prolymphocytic leukemia. | 2 |
| 33658999 | 2020 | CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function. | 12 |
| 32875608 | 2020 | Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype complicating alemtuzumab treatment in T-cell prolymphocytic leukemia. | 2 |
| 33658999 | 2020 | CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function. | 12 |
| 29427418 | 2018 | High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor(-)/CD52(-) T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell-Depleted Allogeneic Stem Cell Transplantation. | 3 |
| 29997173 | 2018 | CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function. | 29 |
| 29427418 | 2018 | High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor(-)/CD52(-) T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell-Depleted Allogeneic Stem Cell Transplantation. | 3 |
| 29997173 | 2018 | CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function. | 29 |
| 24799522 | 2014 | Identification of campath-1 (CD52) as novel drug target in neoplastic stem cells in 5q-patients with MDS and AML. | 20 |
Citation
Dessen P
CD52 (CD52 molecule)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/40043/cd52
