CENPA (centromere protein A)

2003-11-01  

Identity

HGNC
CENPA
LOCATION
2p23.3
LOCUSID
1058
ALIAS
CENP-A,CenH3

Other Information

Locus ID:

NCBI: 1058
MIM: 117139
HGNC: 1851
Ensembl: ENSG00000115163

Variants:

dbSNP: 1058
ClinVar: 1058
TCGA: ENSG00000115163
COSMIC: CENPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115163ENST00000233505P49450
ENSG00000115163ENST00000335756P49450
ENSG00000115163ENST00000419525F8WD88

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383826912024CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer.0
385665542024YTHDC1-dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple-negative breast cancer.1
383826912024CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer.0
385665542024YTHDC1-dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple-negative breast cancer.1
373793352023MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres.2
375961962023The CENP-A nucleosome: where and when it happens during the inner kinetochore's assembly.3
379282732023CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1.3
373793352023MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres.2
375961962023The CENP-A nucleosome: where and when it happens during the inner kinetochore's assembly.3
379282732023CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1.3
354208912022Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.35
362326912022The Sequence Dependent Nanoscale Structure of CENP-A Nucleosomes.4
354208912022Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.35
362326912022The Sequence Dependent Nanoscale Structure of CENP-A Nucleosomes.4
330651122021The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?6

Citation

Dessen P

CENPA (centromere protein A)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40054