CENPE (centromere protein E)

2003-08-01  

Identity

HGNC
LOCATION
4q24
LOCUSID
ALIAS
CENP-E,KIF10,MCPH13,PPP1R61
FUSION GENES

Other Information

Locus ID:

NCBI: 1062
MIM: 117143
HGNC: 1856
Ensembl: ENSG00000138778

Variants:

dbSNP: 1062
ClinVar: 1062
TCGA: ENSG00000138778
COSMIC: CENPE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138778ENST00000265148Q02224
ENSG00000138778ENST00000380026Q02224
ENSG00000138778ENST00000514974D6RHK2
ENSG00000138778ENST00000611174A0A087X0P0

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379344672024A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona.2
384242312024CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments.1
379344672024A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona.2
384242312024CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments.1
376580442023CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly.6
376580442023CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly.6
336455312021Structure and comparison of the motor domain of centromere-associated protein E.1
337420572021A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division.9
339104712021Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis.3
344828032021Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma.9
336455312021Structure and comparison of the motor domain of centromere-associated protein E.1
337420572021A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division.9
339104712021Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis.3
344828032021Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma.9
311742042020Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly.17

Citation

Dessen P

CENPE (centromere protein E)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40056/meetings/gene-fusions/gene-explorer/