CETN2 (centrin 2)

2003-11-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
CALT,CEN2

Other Information

Locus ID:

NCBI: 1069
MIM: 300006
HGNC: 1867
Ensembl: ENSG00000147400

Variants:

dbSNP: 1069
ClinVar: 1069
TCGA: ENSG00000147400
COSMIC: CETN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147400ENST00000370277P41208

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Nucleotide excision repairKEGGko03420
Nucleotide excision repairKEGGhsa03420
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365275742023High expression of CETN2 is associated with platinum resistance and poor prognosis in epithelial ovarian cancer.0
365275742023High expression of CETN2 is associated with platinum resistance and poor prognosis in epithelial ovarian cancer.0
31180055201914-3-3 proteins mediate the localization of Centrin2 to centrosome.2
312028462019Calcium and phosphorylation double-regulating caltractin initiating target protein XPC function.2
314927592019Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.8
31180055201914-3-3 proteins mediate the localization of Centrin2 to centrosome.2
312028462019Calcium and phosphorylation double-regulating caltractin initiating target protein XPC function.2
314927592019Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.8
297939472018Comprehensive Profiling of DNA Repair Defects in Breast Cancer Identifies a Novel Class of Endocrine Therapy Resistance Drivers.45
297939472018Comprehensive Profiling of DNA Repair Defects in Breast Cancer Identifies a Novel Class of Endocrine Therapy Resistance Drivers.45
286369102017Prp40 Homolog A Is a Novel Centrin Target.4
286369102017Prp40 Homolog A Is a Novel Centrin Target.4
257530402015Centrin2 regulates CP110 removal in primary cilium formation.40
263544172015Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function.10
257530402015Centrin2 regulates CP110 removal in primary cilium formation.40

Citation

Dessen P

CETN2 (centrin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40062/cetn2