CHAF1B (chromatin assembly factor 1 subunit B)

2003-12-01  

Identity

HGNC
CHAF1B
LOCATION
21q22.12
LOCUSID
8208
ALIAS
CAF-1,CAF-IP60,CAF1,CAF1A,CAF1P60,MPHOSPH7,MPP7

Other Information

Locus ID:

NCBI: 8208
MIM: 601245
HGNC: 1911
Ensembl: ENSG00000159259

Variants:

dbSNP: 8208
ClinVar: 8208
TCGA: ENSG00000159259
COSMIC: CHAF1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159259ENST00000314103Q13112

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371295732023The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability.5
373778942023Targeting CHAF1B Enhances IFN Activity against Myeloproliferative Neoplasm Cells.0
371295732023The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability.5
373778942023Targeting CHAF1B Enhances IFN Activity against Myeloproliferative Neoplasm Cells.0
350749172022CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection.13
350749172022CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection.13
307201302019CHAF1B promotes proliferation and reduces apoptosis in 95‑D lung cancer cells and predicts a poor prognosis in non‑small cell lung cancer.11
307201302019CHAF1B promotes proliferation and reduces apoptosis in 95‑D lung cancer cells and predicts a poor prognosis in non‑small cell lung cancer.11
297672682018CHAF1B knockdown blocks migration in a hepatocellular carcinoma model.16
297672682018CHAF1B knockdown blocks migration in a hepatocellular carcinoma model.16
240399142013Prognostic significance of EDN/RB, HJURP, p60/CAF-1 and PDLI4, four new markers in high-grade gliomas.24
240399142013Prognostic significance of EDN/RB, HJURP, p60/CAF-1 and PDLI4, four new markers in high-grade gliomas.24
231098372012Tissue microarray-based evaluation of Chromatin Assembly Factor-1 (CAF-1)/p60 as tumour prognostic marker.15
231098372012Tissue microarray-based evaluation of Chromatin Assembly Factor-1 (CAF-1)/p60 as tumour prognostic marker.15
211099522011The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours.16

Citation

Dessen P

CHAF1B (chromatin assembly factor 1 subunit B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40068/teaching-explorer/css/js/web-card-gene.js